Tyrosine hydroxylase inhibition in vitro and in vivo by chelating agents |
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| Authors: | R J Taylor C S Stubbs L Ellenbogen |
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| Affiliation: | 1. Laboratoire de Géologie de Lyon, CNRS UMR 5276, ENS de Lyon, 46 Allée d''Italie, Lyon France;2. Université Bretagne Occidentale (UBO), IUEM (Institut Universitaire Européen de la mer) – UMR 6197, Technopole Brest-Iroise, Place Nicolas Copernic, F-29280 Plouzané, France;3. CNRS, IUEM (Institut Universitaire Européen de la mer) – UMR 6197, Technopole Brest-Iroise, Place Nicolas Copernic, F-29280 Plouzané, France;4. Ifremer, UMR 6197, Technopole Brest-Iroise, Place Nicolas Copernic, F-29280 Plouzané, France;1. Eating Disorders Research and Treatment Program, UCSD Department of Psychiatry, 4510 Executive Dr., Suite 315, San Diego, CA 92121-3021, USA;2. Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136-3326, USA;3. Veterans Affairs San Diego Healthcare System, Research Service, Psychiatry Service, 3350 La Jolla Village Dr., San Diego, CA 92161, USA;4. Medical University of Vienna, Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Waehringer Gurtel 18-20, A-1090 Vienna, Austria;1. Dept. Cellular & Molecular Pharmacology, Rosalind Franklin, Univ.of Medicine & Science, USA;2. Physiology Graduate Training Program, Univ. Wisconsin-Madison, School of Medicine &Public Health, USA;3. College of Agricultural & Life Sciences, Univ. Wisconsin-Madison, USA;4. Dept. Psychiatry, Univ. Wisconsin-Madison, School of Medicine & Public Health, USA |
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| Abstract: | A variety of metal chelating agents inhibited bovine adrenal tyrosine hydroxylase in vitro. Bipyridyl, o-phenanthroline, TPTZ (2,4,6-tripyridyl-s-triazine) and bathophenanthroline (4,7-diphenyl-1,10-phenanthroline), which have high affinities for divalent iron, were the most effective inhibitors. Inhibition by o-phenanthroline was noncompetitive with tyrosine or pteridine cofactor, but dependent on iron concentration. Bipyridyl, administered to rats, inhibited adrenal tyrosine hydroxylase activity and markedly lowered adrenal, heart and brain catecholamines. |
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