| 肿瘤坏死因子-α在中耳胆脂瘤骨质破坏中的作用 |
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| 引用本文： | 薛秋红,金康业,宋海兰. 肿瘤坏死因子-α在中耳胆脂瘤骨质破坏中的作用[J]. 临床耳鼻咽喉头颈外科杂志, 2001, 15(1): 13-14 |
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| 作者姓名： | 薛秋红 金康业 宋海兰 |
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| 作者单位： | 1. 武汉科技大学医学院耳鼻咽喉科
2. 湖北医科大学附属第二医院耳鼻咽喉科 |
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| 摘 要： | 目的 :研究肿瘤坏死因子 - α(TNF- α)在中耳胆脂瘤组织中的表达 ,探讨其在中耳胆脂瘤骨质破坏中的作用。方法 :采用免疫组织化学 SABC染色法和计算机图像定量分析法 ,对 2 5例中耳胆脂瘤和 10例正常外耳道皮肤中 TNF- α的表达情况进行观察。结果 :TNF- α不仅在胆脂瘤上皮的各层细胞胞浆中 ,而且在皮下组织的炎性细胞中都有高度表达。定量分析显示胆脂瘤上皮中 TNF- α的含量显著高于外耳道皮肤 (P <0 .0 5 )。结论 :TNF-α可能是胆脂瘤引起骨质破坏的一个因素。
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| 关 键 词： | 中耳胆脂瘤 肿瘤坏死因子-α 骨质破坏 |
| 文章编号： | 1001-1781(2001)01-0013-02 |
| 修稿时间： | 2000-04-24 |
The study of TNF- |
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| XUE Qiuhong,JIN Kangye,SONG Hailan. The study of TNF-[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2001, 15(1): 13-14 |
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| Authors: | XUE Qiuhong JIN Kangye SONG Hailan |
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| Affiliation: | Department of Otolaryngology, Medical College of Wuhan, Science and Technology University, Wuhan 430062. |
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| Abstract: | OBJECTIVE: To study the expression of TNF-alpha in the cholesteatoma and elucidate the role of TNF-alpha in the destruction of bone. METHOD: All samples (5 microns paraffin sections) from 25 cholesteatoma cases and 10 normal cases were examined by immunohistochemical SABC method and analysed by computer image. RESULT: In 25 cholesteatoma cases, TNF-alpha expressed in the cytoplasm of the full epithelial tissue cells, subcutaneous inflammatory cells and fibroblast. In contrast, the normal cases, there were 6 cases week positive, 4 cases negative. The results of the computer image quantitative analysis system showed that the mean optical density of TNF-alpha was 0.1326 +/- 0.0022 in the cholesteatoma epithelial tissue and 0.0868 +/- 0.0014 in normal skin epithelial tissue respectively, both of which had significantly differentiation (P < 0.05). CONCLUSION: TNF-alpha may be a factor of the destruction of bone of cholesteatoma. |
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