| 周围神经损伤后大鼠背根神经节细胞NMDA受体表达的可塑性改变 |
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| 引用本文： | 谭爱娟,令狐清溪,王瑞. 周围神经损伤后大鼠背根神经节细胞NMDA受体表达的可塑性改变[J]. 山西医科大学学报, 2002, 33(2): 97-98 |
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| 作者姓名： | 谭爱娟 令狐清溪 王瑞 |
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| 作者单位： | 1. 山西医科大学神经生物学研究室,太原,030001
2. 山西医科大学第一临床医学院口腔科 |
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| 摘 要： | 目的 观察外周神经切断后初级感觉神经元内N-甲基-D-天冬氨酸（NMDA）受体表达的改变。方法 采用免疫细胞化学技术显示背根节内NMDAR1（NMDAR1-LI）阳性细胞数。结果 坐骨神经切断后大鼠腰段背根节内NMDAR1的表达显著下调。结论 外周神经损伤后，初级感觉神经元NMDA受体发生可塑性改变，提示脊髓内谷氨酸递质活动的改变。
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| 关 键 词： | 周围神经损伤 大鼠 背根神经节细胞 NMDA受体 表达 可塑性改变 |
| 文章编号： | 1007-6611(2002)02-0097-02 |
Plasticity of NMDA receptor expression in rat dorsal root ganglion after peripheral nerve injury |
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| TAN Ai-juan,LINGHU Qing-xi,WANG Rui. Plasticity of NMDA receptor expression in rat dorsal root ganglion after peripheral nerve injury[J]. Journal of Shanxi Medical University, 2002, 33(2): 97-98 |
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| Authors: | TAN Ai-juan LINGHU Qing-xi WANG Rui |
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| Abstract: | Objective To observe the effect of axotomy on the expression of NMDA receptors in the primary sensory neurons of rats. Methods The numbers of NMDAR1-like immunoreactivity(-LI) cells in rat lumbar dorsal root ganglia (DRGs) were analysed using immunocytochemistry.Results The expression of NMDAR1 in lumbar DRGs was dramatically down-regulated after sciatic nerve section.Conclusion Following nerve section, NMDA receptors undergo plastic changes in their expression in DRG neurons, suggesting changes of glutamatic transmission in the spinal cord. |
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| Keywords: | peripheral nerve wounds and injuries receptors N-methyl-D-aspartate ganglia spinal neuronal plasticity rats |
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