预混辅料直接压片的性质考察

目的 考察几种预混辅料的性质。方法 以粒度分布、休止角、堆密度为指标，考察预混辅料的粉体学性质，并将预混辅料应用于粉末直接压片工艺中。结果 与普通辅料淀粉、微晶纤维素相比，预混辅料直压淀粉、直压微晶纤维素的休止角、压缩度小，流动性好。结论 预混辅料的粉体学性质优于普通辅料，且粉末直接压片法所得片剂质量良好。

Property of direct compression on co-processed excipients

Objective To investigate the properties of several co-processed excipients. Methods The characteristics of co-processed excipients were investigated by taking the size distribution, angle of repose, and bulk density as indexes, and excipients were applied to the direct compression. Results Compared with starch and microcrystalline cellulose, direct pressure starch and direct pressure microcrystalline cellulose had smaller repose angle and aerated bulk density, as well as excellent flow ability. Conclusion Compared with ordinary excipients, co-processed excipients show superior micromeritic characteristics, and we can obtain tablets of good quality by direct powder compression.