聚乳酸乙醇酸在微球控释制剂中的研究进展

聚乳酸乙醇酸（PLGA）是生物可降解的聚合物，已取得了美国FDA的批准，用于组织工程支架和药物载体。由于其具有良好的生物相容性和生物可降解性，近20年来成为小分子药物、蛋白质和其他大分子（DNA、RNA或多肽类）化合物的缓释控释制剂研究的热点。对于PLGA微球制剂的研究主要集中在疫苗类、激素类、抗生素类、抗肿瘤类、神经营养物质类等药物控释制剂。主要介绍近5年来这些药物微球的研究情况，为进一步开发利用PLGA作为药物载体提供参考。

Advances in studies on drug carrier poly lactic-co-glycolic acid in controlled release microspheres

Poly lactic-co-glycolic acid (PLGA) is a biodegradable polymer used to fabricate devices for drug delivery and tissue engineering scaffolds, and has been approved by the FDA in US. Its application in fabrication of devices for drug delivery, including small molecular drug, protein and other macromolecules (DNA, RNA or peptides) has become a hot spot of study in recent two decades for its good biodegradability, and biocompatibility. Most studies focused on controlled release microspheres of vaccine, hormone, antibiotics, anticancer agent, neurotrophic active substances, etc. This paper describes some studies on these controlled release microspheres in recent five years.