Steroid hormones, anti-inflammatory steroids and prostaglandins. |
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| Authors: | R J Gryglewski |
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| Affiliation: | 1. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;2. Digestive Disease Center, Department of Internal Medicine, SoonChunHyang University School of Medicine, SoonChunHyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon 14584, Republic of Korea;1. Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland;2. Department of Pharmacology, Jagiellonian University, Medical College, Krakow, Poland |
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| Abstract: | Hydrocortisone and synthetic anti-inflammatory steroids inhibit the release of prostaglandins from intact cells, tissues and organs, but do not inhibit conversion of arachidonic acid by microsomal cyclooxygenase to prostaglandins. This type of activity implies the possibility of a direct interaction of corticosteroids with biomembranes, which might either impair the supply of endogenous substrates for prostaglandin biosynthesis or inhibit transmembrane transport of prostaglandins. |
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