| 五味子乙素和五味子酚对药物代谢Ⅱ相酶及雌二醇... |
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| 引用本文： | 卢华 刘耕陶. 五味子乙素和五味子酚对药物代谢Ⅱ相酶及雌二醇...[J]. 中国药理学报, 1990, 11(4): 331-335 |
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| 作者姓名： | 卢华 刘耕陶 |
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| 摘 要： |
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| 关 键 词： | 五味子乙素 五味子酚 雌二醇 |
Effects of schizandrin B and schisanhenol on drug metabolizing-phase II enzymes and estradiol metabolism |
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| H Lu,G T Liu. Effects of schizandrin B and schisanhenol on drug metabolizing-phase II enzymes and estradiol metabolism[J]. Acta Pharmacologica Sinica, 1990, 11(4): 331-335 |
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| Authors: | H Lu G T Liu |
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| Affiliation: | Department of Pharmacology, Chinese Academy of Medical Sciences, Beijing. |
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| Abstract: | Intragastric gavage of schizandrin B (Sin B) and schisanhenol (Sal) 200 mg/kg once daily for 3 d significantly increased liver glutathione-S-transferase (GSH-S-T) and microsomal cytochrome P-450 in mice and rats. Sin B and Sal antagonized the increase of uterus weight induced by sc estradiol in ovariectomized, and decreased serum estradiol level in mice. RIA and HPLC showed an enhancement in [3H] estradiol metabolism by liver microsomes from Sin B- and Sal-treated mice. The results indicated that both Sin B and Sal have inductive actions on drug metabolizing-phase I and phase II enzymes in mice and rats. |
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