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Mechanism of Viral Suppression among HIV Elite Controllers and Long-Term Nonprogressors in Nigeria and South Africa |
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| Authors: | Rahaman Ademolu Ahmed Khalid Olajide Adekoya Chika Kingsley Onwuamah Bolanle Olufunmilayo Oboh Smita Swaminathan Iyer Ayomide Samuel Oluwatosin Rosemary Ajuma Audu Oliver Chukwujekwu Ezechi |
| Affiliation: | 1.Cell Biology and Genetics Department, University of Lagos, Lagos 101017, Nigeria; (K.O.A.); (B.O.O.);2.Center for Human Virology and Genomics, Microbiology Department, Nigerian Institute of Medical Research, Lagos 100001, Nigeria; (C.K.O.); (A.S.O.); (R.A.A.);3.The Center for Immunology and Infectious Diseases, University of California, Davis, CA 95616, USA;4.Clinical Science Department, Nigerian Institute of Medical Research, Lagos 100001, Nigeria; |
| Abstract: | A subgroup among people living with HIV (PLHIV) experience viral suppression, sometimes to an undetectable level in the blood and/or are able to maintain a healthy CD4+ T-cell count without the influence of antiretroviral (ARV) therapy. One out of three hundred PLHIV fall into this category, and a large sample of this group can be found in areas with a high prevalence of HIV infection such as Nigeria and South Africa. Understanding the mechanism underpinning the nonprogressive phenotype in this subgroup may provide insights into the control of the global HIV epidemic. This work provides mechanisms of the elite control and nonprogressive phenotype among PLHIV in Nigeria and South Africa and identifies research gaps that will contribute to a better understanding on HIV controllers among PLHIV. |
| Keywords: | HIV elite controllers viraemic controllers long-term nonprogressors Nigeria South Africa |