Synergism between anti-rhinovirus antivirals: Various human interferons and a number of synthetic compounds |
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| Affiliation: | 1. Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India;2. Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India;3. Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India;4. Department of Microbiology, Kasturba Medical College, Mangaluru, Manipal Academy of Higher Education (MAHE), India;5. Department of Community Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India;6. Australian Rickettsial Reference Laboratory, Geelong, VIC, Australia;7. Department of Infectious Diseases, Barwon Health, Australia;8. Department of Microbiology, Melaka Manipal Medical College, Manipal Campus, Manipal Academy of Higher Education (MAHE), Manipal, India;1. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine; The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, 1200 Cailun Rood, Shanghai 201203, China;2. Shanghai R&D Centre for Standardization of Chinese Medicines, 199 Guoshoujing Road, Shanghai 201210, China |
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| Abstract: | DCF (dichloroflavan), enviroxime, chalcone Ro-09-0410 and HuIFN (Human interferon)-α2, HuIFN-β, HuIFN-β × 401 and HuIFN-γ, showed antiviral activity in vitro against RV2 (rhinovirus type 2) and RV9.Binary combinations of these drugs showed synergistic activity of which the combinations of HuIFN-γ or HuIFN-α and enviroxime were of most interest. They were studied in more detail in tissue culture by virus yield experiments and in organ culture of human embryonic nasal epithelium and human embryonic tracheal culture in which there was a potent antiviral synergy. These results indicate that such combinations of drugs may be worthy of clinical study. |
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