Influenza B: Prospects for the Development of Cross-Protective Vaccines |
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| Authors: | Liudmila M. Tsybalova Liudmila A. Stepanova Edward S. Ramsay Andrey V. Vasin |
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| Affiliation: | 1.Smorodintsev Research Institute of Influenza, Prof. Popova Str., 15/17, 197376 St. Petersburg, Russia; (L.A.S.); (E.S.R.); or (A.V.V.);2.Research Institute of Influenza named after A.A. Smorodintsev, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya, 29, 195251 St. Petersburg, Russia |
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| Abstract: | In this review, we analyze the epidemiological and ecological features of influenza B, one of the most common and severe respiratory infections. The review presents various strategies for cross-protective influenza B vaccine development, including recombinant viruses, virus-like particles, and recombinant proteins. We provide an overview of viral proteins as cross-protective vaccine targets, along with other updated broadly protective vaccine strategies. The importance of developing such vaccines lies not only in influenza B prevention, but also in the very attractive prospect of eradicating the influenza B virus in the human population. |
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| Keywords: | influenza B virus phylogenetic lineages viral proteins monoclonal antibodies cross-protection vaccines |
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