Dietary Glycemic Load and Plasma Amyloid-β Biomarkers of Alzheimer’s Disease |
| |
Authors: | Mlissa Gentreau Michel Raymond Ccilia Samieri Virginie Chuy Catherine Fart Claire Berticat Sylvaine Artero |
| |
Institution: | 1.Institute of Functional Genomics (IGF), University of Montpellier, CNRS, INSERM, F-34094 Montpellier, France;2.ISEM, University of Montpellier, CNRS, EPHE, IRD, F-34095 Montpellier, France; (M.R.); (C.B.);3.Bordeaux Population Health Research Center, University of Bordeaux, INSERM, BPH, UMR 1219, F-33000 Bordeaux, France; (C.S.); (V.C.); (C.F.);4.CHU de Bordeaux, Pôle de Médecine et Chirurgie Bucco-Dentaire, F-33000 Bordeaux, France |
| |
Abstract: | Previous studies have highlighted links between a high-glycemic-load (GL) diet and Alzheimer’s disease in apolipoprotein E ε4 (APOE4) carriers. However, the impact of high-GL diet on plasma amyloid-β (Aβ), an Alzheimer’s disease hallmark that can be detected decades before clinical symptomatology, is unknown. This study examined the association between plasma Aβ peptides (Aβ40, Aβ42 concentration and Aβ42/Aβ40 ratio) and GL. The influence of the GL of four meal types (breakfast, lunch, afternoon snack, and dinner) was also determined. From the prospective Three-City study, 377 participants with plasma Aβ measurements, and who completed the Food Frequency Questionnaire, were selected. The association between plasma Aβ and GL was tested using an adjusted linear regression model. Lunch GL was associated with a lower plasma Aβ42 concentration (β = −2.2 CI = −4.27, −0.12], p = 0.038) and lower Aβ42/Aβ40 ratio (β = −0.009 CI = −0.0172, −0.0007], p = 0.034) in the model adjusted for center, age, sex, education level, APOE4 status, energy intake, serum creatinine, total cholesterol, and Mediterranean-like diet. No significant association was found with the GL of the other meal types. These results suggest that dietary GL may independently modulate the plasma Aβ of the APOE4 status. The mechanism underlying diet, metabolic response, and Aβ peptide regulation must be elucidated. |
| |
Keywords: | glycemic load refined carbohydrate amyloid-β Alzheimer’ s disease biomarker cohort |
|
|