新生儿期先天梅毒36例临床分析

目的：探讨新生儿期先天梅毒的临床表现特点。方法：总结分析36例新生儿期先天梅毒，观察患儿临床及实验室检查的改变。结果：无症状新生儿期先天梅毒占61％；新生儿期先天梅毒症状和体征主要有皮疹、肝脾肿大、肺部感染，36例患儿中，早产儿13例（36％），新生儿死亡5例（14％），血清学USR、TPPA、19SIgM—TPPA检测结果均为阳性，肝功能异常23例（64％），肾功能异常22例（61％）。结论：新生儿先天梅毒的诊断须结合临床体征、实验室诊断结果以及母亲的病史进行综合分析；妊娠梅毒患者应及时发现、诊断并给予规范治疗，才能有效地阻断先天梅毒的发生。

Analysis of 36 Neonatal Congenital Syphilis Cases

Objective: To characterize the clinic manifestations and understand the features of neonatal congenital syphilis.Methods: The clinical and laboratory data of 63 neonetal congerntal syphilis were analysed.Results: Brief clinical data were: premature delivery 36%,death 14%,and asymptomatic congenital syphilis 61%.Clinical signs and symptoms of these cases included skin rashes,pulmonary infection,enlargement of liver and spleen and blood abnormalities.All cases showed positive results of TRUST,TPPA and 19S-IgM-TPPA.Twenty-three cases had liver function damage.Twenty-two cases had renal function damage.Conclusions: Neonatal congenital syphilis should be diagnosed according to the clinic history,symptoms and the results of laboratory tests of the mothers and their children;typical skin symptoms can be used to diagnose neonatal congenital syphilis,but most cases are asymptomatic(22/36,61%).In order to control the occurrence of neonatal congenital syphilis,antenatal routine screening and treatment for pregnant syphilis must be strengthened.