| 中药对脊髓损伤大鼠背根神经节c-Jun表达的影响 |
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| 引用本文： | 高秀来,韩凤岳,等.中药对脊髓损伤大鼠背根神经节c-Jun表达的影响[J].首都医学院学报,2001,22(4):292-295. |
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| 作者姓名： | 高秀来 韩凤岳 |
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| 作者单位： | [1]首都医科大学解剖学教研室 [2]中国中医研究所骨伤科研究所 |
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| 基金项目： | 北京市教委1997年基金资助项目 |
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| 摘 要： | 应用荧光免疫组化法及激光扫描共聚焦显微镜技术，探索中药脊髓I号促进大鼠损伤脊髓修复再生的机制。结果表明，服用脊髓I号后脊髓损伤侧背根节神经元的c-Jun表达明显上调；脊髓损伤侧背根节神经元的细胞核呈完整形态的数量明显增多。提示脊髓I号可能通过对c-Jun基因表达的调节，激发损伤脊髓组织的修复再生。
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| 关 键 词： | 中药 脊髓 再生 背根神经节 c-Jun表达 |
| 收稿时间： | 2001-06-29 |
| 修稿时间： | 2001年6月29日 |
Effect of Chinese Herb on c-Jun Expression in Dorsal Root Ganglia in Rats with Spinal Cord Hemisection |
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| Gao Xiulai,Jing Peng,Hao Yanli,Ma Yuping,Chen Yaliang,Lu Tao,Han Fengyue,Su Jing,Liu Weidong,Zhang Ping,Chang Chaoying,Liu En.Effect of Chinese Herb on c-Jun Expression in Dorsal Root Ganglia in Rats with Spinal Cord Hemisection[J].Journal of Capital University of Medical Sciences,2001,22(4):292-295. |
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| Authors: | Gao Xiulai Jing Peng Hao Yanli Ma Yuping Chen Yaliang Lu Tao Han Fengyue Su Jing Liu Weidong Zhang Ping Chang Chaoying Liu En |
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| Institution: | 1. Department of Anatomy, Capital University of Medical Sciences;2. Institute of Orthopaedics and Traumatology, China Acad |
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| Abstract: | The object was to study the mechanism of promoting spinal cord regeneration and repair in rats with SCI after spinal cord injury by fluorescence immunohistochemical method combined with laser scanning confocal microscopy. The results indicated that the up-regulation of c-Jun was heightened in dorsal root ganglia of the injury side by the administration of SCI and the number of nerve cells with intact nuclear in SCI administration group was higher. This study showed that SCI could regulate c-Jun expression and promote regeneration of the spinal cord. |
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| Keywords: | Chinese herb spinal cord regeneration dorsal root ganglia c-Jun expression |
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