High expressions of vascular endothelial growth factor and platelet-derived endothelial cell growth factor predict poor prognosis in alpha-fetoprotein-negative hepatocellular carcinoma patients after curative resection |
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Authors: | Jie Hu Yang Xu Zao-Zhuo Shen Zheng Wang Qing Lu Guo-Huan Yang Zheng-Bin Ding Jia Fan Jian Zhou |
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Institution: | (1) Key Laboratory for Carcinogenesis & Cancer Invasion, The Chinese Ministry of Education, Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, 136 Yi Xue Yuan Road, 200032 Shanghai, People’s Republic of China;(2) Institute of Biomedical Sciences, Fudan University, 200032 Shanghai, People’s Republic of China |
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Abstract: | Purpose To evaluate the prognosis value of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth
factor (PD-ECGF) in alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) patients after curative resection.
Methods Tumor tissue microarrays (TMAs) were used to detect the expressions of VEGF and PD-ECGF in consecutive 162 AFP-negative HCC
patients undergoing curative resection between 1997 and 2000 in our institute. Clinicopathologic data for these patients were
evaluated. The prognostic significance was assessed using Kaplan–Meier survival estimates and log-rank tests. Multivariate
study with Cox’s proportional hazard model was used to evaluate the prognosis-related aspects.
Results The positive rates of VEGF and PD-ECGF in tumor tissues were 59.9% (97/162) and 62.3% (101/162), respectively. Univariate
analysis showed that VEGF and PD-ECGF were prognostic factors for relapse-free survival (P = 0.034 and P = 0.033, respectively). Multivariate analyses demonstrated that the co-index (VEGF/PD-ECGF) was an independent prognostic
factor for overall survival and relapse-free survival (P = 0.002 and P = 0.000, respectively).
Conclusion The co-index of VEGF and PD-ECGF is a promising independent predictor for recurrence and survival of AFP-negative HCC patients
after curative resection.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
J. Hu, Y. Xu and Z.-Z. Shen have contributed equally to this work. |
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Keywords: | Hepatocellular carcinoma Vascular endothelial growth factor Platelet-derived endothelial cell growth factor Prognosis Tissue microarrays |
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