Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4+ Treg |
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| Authors: | Horwitz David A Zheng Song Guo Wang Juhua Gray J Dixon |
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| Affiliation: | Division of Rheumatology and Immunology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA. dhorwitz@usc.edu |
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| Abstract: | CD4+Foxp3+ Treg consist of two indistinguishable subsets induced in either the thymus or the periphery. In addition to their suppressive activities, IL-6 can convert natural Treg to pro-inflammatory IL-17-producing cells, but those induced with IL-2 and TGF-beta remain Treg. Unlike mouse CD4+CD25(-) cells, which rapidly become polyclonal Foxp3+CD25+ Treg when activated appropriately with IL-2 and TGF-beta, human T cells require multiple stimulations to become similar suppressor cells. |
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| Keywords: | Foxp3 IL‐2 IL‐6 Regulatory cells TGF‐β |
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