| 芪参健骨颗粒的提取工艺研究 |
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| 引用本文： | 尹华,张春霞,章建华,王知青. 芪参健骨颗粒的提取工艺研究[J]. 中国现代应用药学, 2011, 28(12): 1106-1109 |
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| 作者姓名： | 尹华 张春霞 章建华 王知青 |
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| 作者单位： | 1.浙江中医药大学药学院中药标准化研究实验室，杭州 310053；2.浙江中医药大学附属第一医院，杭州 310006 |
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| 基金项目： | 浙江省科技厅科技计划项目(2006C33003)；浙江省中药现代化专项资金和浙江省中医药重点开发项目(2004Z004) |
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| 摘 要： | 目的 优选芪参健骨颗粒的最佳提取工艺。方法 采用单因素试验和L9（3^4）正交试验法，考察药材粒度、浸泡时间、溶媒用量、提取时间和提取次数等因素的影响，以黄芪甲苷、丹酚酸B的转移率为指标，采用多指标综合评分法（权重系数为黄芪甲苷∶丹酚酸B=0.6∶0.4）确定最佳提取工艺。结果 芪参健骨颗粒的最佳提取工艺为药材饮片浸泡1 h，以12倍量水提取3次，每次0.5 h。结论 优选的提取工艺方法可行、工艺稳定、重复性好。
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| 关 键 词： | 芪参健骨颗粒 提取工艺 正交试验 黄芪甲苷 丹酚酸B |
| 收稿时间： | 2010-07-23 |
Study on the Extractive Technology of Qishen Jiangu Granules |
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| YIN Hu,ZHANG Chunxi,ZHANG Jianhu,WANG Zhiqing. Study on the Extractive Technology of Qishen Jiangu Granules[J]. The Chinese Journal of Modern Applied Pharmacy, 2011, 28(12): 1106-1109 |
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| Authors: | YIN Hu ZHANG Chunxi ZHANG Jianhu WANG Zhiqing |
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| Affiliation: | 1.Research Laboratory for Standardization of Chinese Medicines, College of Pharmacy, Zhejiang Chinese Medicine University, Hangzhou 310053, China; 2.Zhejiang Chinese Medical University, First Affiliated Hospital, Hangzhou 310006, China |
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| Abstract: | OBJECTIVE To optimize the extractive technology of Qishen Jiangu granules. METHODS The single-factor experiment and orthogonal experiment were used to determine the optimal conditions including granularity of medicine, sunk time, solvent amount, extraction time and times with the transfer rates of astragaloside IV and salvianolic acid B as the index, and multi-index score method （weight coefficient： astragaloside IV∶salvianolic acid B=0.6∶0.4）. RESULTS The optimized conditions were determined as follows： the sunk time was 1 h, 12 times volumn of water was used to extract medicine decoction pieces for 3 times, extraction time was 0.5 h. CONCLUSION The optimized process is feasible, stable and replicable. |
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| Keywords: | Qishen Jiangu granules extractive technology orthogonal test astragaloside IV salvianolic acid B |
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