胰腺癌患者围手术期机体免疫功能的变化

目的：探讨胰腺癌患者围手术期机体免疫功能的变化。方法：动态观察４０例胰腺癌患者围手术期外周血Ｔ淋巴细胞亚群、红细胞免疫功能指标ＲＢＣ－Ｃ３dＲ和ＲＢＣ－ＩＣＲ明 显增高，血清免疫球蛋白ＩgＧ水平也呈升高趋势。其中Ｔ淋巴细胞亚群与红细胞免疫功能指标的变化具有一定的相关必。与胰腺癌未切除组相比，胰腺癌切除组碑术后２周Ｔ淋巴细胞亚群、红细胞免疫功能指标和血清免功能球蛋白ＩgＧ逐渐趋于恢复，术后３０d基本恢复

Changes of the immune function in patients with pancreatic cancer

Objective: To investigate the changes of immune function in patients with pancreatic cancer. Methods: The T lymphocyte subgroup, the immune function of red blood cell and serum immunoglobulin of 40 patients with pancreatic cancer during preoperative and postoperative period were observed dynamically. Results: CD3, CD4, CD4/CD8 ratio and RBC C3bR were significantly decreased preoperatively, while CD3 and RBC ICR were increased markedly. The level of serum IgG was also higher than normal. The changes of T lymphocyte subgroup were significantly associated with immune function of red blood cells. The T lymphocyte subgroup and the immune function of red blood cell in patients received radical treatment recovered gradually 2 weeks after operation and showed nearly the normal level after 30 d postoperatively. Conclusion: The immune function system in patients with pancreatic cancer is defected to different degrees. Operative treatment can recover the immune function in these cases. On the other hand, the investigation of immune system in patients with cancer consists not only of granulocyte immune system but also the blood cell immune system.