| Interleukin 17-Producing γδ T Cells Increased in Patients with Active Pulmonary Tuberculosis |
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| 作者姓名： | Peng MY Wang ZH Yao CY Jiang LN Jin QL Wang J Li BQ |
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| 作者单位： | [1]Department of Immunology, Bengbu Medical College, and Anhui KeyLaboratory of Infection and Immunity at Bengbu Med cal College, 2600Dong hai Avenue, Bengbu, Anhui 233030, China; [2]The Infectious Disease Hospital of Bengbu, 160 Third Hongqi Road,Bengbu, Anhui 233000, China; [3]Department of Immunology, Bengbu Medical College, 2600 Dong Hal Avenue, Bengbu, Anhui 233030, China |
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| 基金项目： | This work was sponsored by Key Program of Natural Science Research （No. ZD2007010-1） and Key Research Program for Key Laboratory of Universities in Anhui （No. 2004sys008） from The Anhui Provincial Education Department.
We thank the staff in the Department of Pulmonary of the Infectious Disease Hospital of Bengbu for their help in collection of specimen of TB patients, and thank our colleagues at the Anhui Key Laboratory of Infection and Immunity and Department of Immunology, Bengbu Medical College for their technical support and academic discussion in this protocol. |
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| 摘 要： | Although it has been known that γδ T cells may play an important role in the immune response to infection of Mycobacterium tuberculosis （M. tb）, the mechanisms by which the γδ T cells participate in the innate and/or acquired immunity to tuberculosis （TB） have not been full elucidated. In the present study, 27 patients with active pulmonary TB and 16 healthy donors （HD） were performed. We found that proportion of IL-17-producing cells among lymphocyte was similar between TB patients and HD, whereas the proportions of γδ T cells in IL-17-producing cells （59.2%） and IL-17-producing cells in γδ T cells （19.4%） in peripheral blood were markedly increased in TB patients when compared to those in HD （43.9% and 7.7%, respectively）. In addition, the proportions of IFN-T-producing γδ T cells in TB patients were obviously lower than that in HD. Upon re-stimulated with M. tb heat-treated antigen （M. tb-HAg） in vitro, fewer IL-17-producing γδ T cells were generated from HD and TB patients, whereas IFN-T-producing γδ T cells were increased in TB patients compared to that in HD. Our findings in TB patients and healthy human were consistent with other murine investigation that the IL-17- producing γδ T cells were main source of IL-17 in mouse model of BCG infection, suggesting that γδ T cells might be involved in the formation of tubercular granuloma in pulmonary TB patients, but need further identification.
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| 关 键 词： | 分支杆菌 结核病 γδ T细胞 IL-17 肺结核 |
| 收稿时间： | 2008 Feb 13 |
Interleukin 17-producing gamma delta T cells increased in patients with active pulmonary tuberculosis |
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| Peng MY,Wang ZH,Yao CY,Jiang LN,Jin QL,Wang J,Li BQ.Interleukin 17-producing gamma delta T cells increased in patients with active pulmonary tuberculosis[J].Cellular ＆ Molecular Immunology,2008,5(3):203-208. |
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| Authors: | Peng Mei Yu Wang Zhao Hua Yao Chun Yan Jiang Li Na Jin Qi Li Wang Jing Li Bai Qing |
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| Institution: | Department of Immunology, Bengbu Medical College, and Anhui Key Laboratory of Infection and Immunity at Bengbu Medical College, Bengbu, Anhui, China. |
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| Abstract: | Although it has been known that gammadelta T cells may play an important role in the immune response to infection of Mycobacterium tuberculosis (M. tb), the mechanisms by which the gammadelta T cells participate in the innate and/or acquired immunity to tuberculosis (TB) have not been full elucidated. In the present study, 27 patients with active pulmonary TB and 16 healthy donors (HD) were performed. We found that proportion of IL-17-producing cells among lymphocyte was similar between TB patients and HD, whereas the proportions of gammadelta T cells in IL-17-producing cells (59.2%) and IL-17-producing cells in gammadelta T cells (19.4%) in peripheral blood were markedly increased in TB patients when compared to those in HD (43.9% and 7.7%, respectively). In addition, the proportions of IFN-gamma-producing gammadelta T cells in TB patients were obviously lower than that in HD. Upon re-stimulated with M. tb heat-treated antigen (M. tb-HAg) in vitro, fewer IL-17-producing gammadelta T cells were generated from HD and TB patients, whereas IFN-gamma-producing gammadelta T cells were increased in TB patients compared to that in HD. Our findings in TB patients and healthy human were consistent with other murine investigation that the IL-17-producing gammadelta T cells were main source of IL-17 in mouse model of BCG infection, suggesting that gammadelta T cells might be involved in the formation of tubercular granuloma in pulmonary TB patients, but need further identification. |
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| Keywords: | Mycobacterium tuberculosis γδ T cell IL-17 pulmonary tuberculosis |
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