p38丝裂原活化蛋白激酶与骨代谢

丝裂原活化蛋白激酶（mitogen-activated protein kinases,MAPK）是机体广泛表达的丝氨酸/酪氨酸激酶,在哺乳动物细胞多种信号转导通路中起重要作用。p38MAPK信号通路是MAPK通路的一个重要分支,在细胞增殖、分化、凋亡和细胞周期调控等多种生理和病理过程中发挥重要作用。近年来,有关p38MAPK信号通路在与骨代谢相关的破骨细胞、成骨细胞、软骨细胞生长、代谢及功能方面的研究倍受关注。本文就p38MAPK与骨代谢相关研究进展进行综述,旨在探讨p38MAPK在骨代谢相关疾病中的作用机制。

p38 Mitogen-activated protein kinases and bone metabolism

Mitogen-activated protein kinase(MAPK)is a serine/tyrosine kinase which is expressed widely and regulates various signal transduction pathways in mammalian cell.As one of the key branches of MAPK pathway,p38 MAPK signaling pathway plays an important role in various physiological and pathological processes,such as cell proliferation,differentiation,apoptosis and cell cycle regu-lation.In recent years,the research on p38MAPK signaling pathway in cell growth,metabolism and function of osteoclast,osteoblast and...