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| MMP-7蛋白表达与脊索瘤的相关性研究 | |
| 引用本文： | 韩壮,吕刚,邓博雅,陈鹏,赵伟.MMP-7蛋白表达与脊索瘤的相关性研究[J].中国医科大学学报,2005,34(1):64-65. |
| 作者姓名： | 韩壮 吕刚 邓博雅 陈鹏 赵伟 |
| 作者单位： | 1. 中国医科大学附属第一医院骨科,辽宁,沈阳,110001 2. 中国医科大学85期七年制 3. 沈阳市第一人民医院外二科 4. 沈阳市中心医院骨科 |
| 摘 要： | 目的:探讨MMP-7基因表达与脊索瘤发生的可能关系.方法:应用免疫组化(S-P)方法,对18例脊索瘤患者的肿瘤和瘤旁正常组织的MMP-7蛋白表达进行检测.结果:脊索瘤中MMP-7蛋白表达阳性百分比为83.3%(15/18),瘤周正常组织为33.3%(6/18),MMP-7蛋白在脊索瘤中表达增高(P＜0.01).结论:MMP-7蛋白表达改变可能与脊索瘤的发生机制有关. |
| 关 键 词： | 脊索瘤 MMP-7蛋白 免疫组化 |
| 文章编号： | 0258-4646(2005)01-0064-02 |
| 修稿时间： | 2004年5月20日 |
Expression of matrix metalloproteinase-7 protein in human chordoma |
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| HAN Zhuang,U Gang,DENG Bo-ya,CHEN Peng,ZHAO Wei.Expression of matrix metalloproteinase-7 protein in human chordoma[J].Journal of China Medical University,2005,34(1):64-65. | |
| Authors: | HAN Zhuang U Gang DENG Bo-ya CHEN Peng ZHAO Wei |
| Abstract: | Objective: To investigate the possible relationship between matrix metalloproteinase-7 (MMP-7) and human chordoma, and to determin its effects in tumor invasion and metastasis. Methods: Pari-tumor and cancerous tissues from 18 patients with chordoma were analyzed by using immunohistochemistry(S-P) methods. Results: The positive rate of MMP-7 protein in cancerous tissues was 83.3%(15/18),and 33.3%(6/18) in peri-tumor tissue. Image analysis indicated that statistic difference can be observed between cancerous and peri-tumor tissue (P<0.01). The MMP-7 protein highly expressed in chordoma. Conclusion: High expression of MMP-7 protein in chordoma may be very important in carcinogenesis and invasion of chordoma. |
| Keywords: | chordoma matrix metalloproteinase-7 protein immunohistochemistry |
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