田基黄的化学成分研究

 目的研究田基黄(Hypericum japonicum Thunb.)的化学成分。方法运用多种色谱技术对田基黄的化学成分进行系统研究,根据光谱数据鉴定化合物结构。结果分离鉴定了12个化合物,分别为:异巴西红厚壳素(Ⅰ),槲皮素(Ⅱ),山柰酚(Ⅲ),槲皮素-7-O-α-L-鼠李糖苷(Ⅳ),槲皮苷(Ⅴ),异槲皮苷(Ⅵ),槲皮素-3-O-β-D-葡萄糖醛酸苷(Ⅶ),田基黄双酮(Ⅷ),3,8″-biapigenin(Ⅸ),白桦酸(Ⅹ),豆甾醇(Ⅺ),豆甾醇-3-O-β-D-葡萄糖苷(Ⅻ)。结论化合物Ⅶ,Ⅸ,Ⅻ为首次从该植物中分离得到。

Studies on Chemical Constituents of Hypericum japonicum

OBJECTIVE To investigate the chemical constituents of Hypericum japonicum.METHODS The compounds were separated by chromatography and their chemical structures were elucidated by means of MS,1H-NMR and 13C-NMR spectral methods,respectively.RESULTS Twelve compounds were isolated from the plant,they were identified as isojacareubin(Ⅰ),quercetin(Ⅱ),kaempferol(Ⅲ),quercetin-7-O-α-L-rhamnoside(Ⅳ),quercitrin(quercetin-3-O-α-L-rhamnoside,Ⅴ),isoquercitrin(quercetin-3-O-β-D-glucoside,Ⅵ),miguelianin(quercetin-3-O-β-D-glucuronide,Ⅶ),bijaponicaxanthone(Ⅷ),3,8″-biapigenin(Ⅸ),betulinic acid(Ⅹ),stigmasterol(Ⅺ) and stigmasterol-3-O-β-D-glucopyranoiside(Ⅻ).CONCLUSION Compound Ⅶ,Ⅸ and Ⅻ are isolated from this plant for the first time.