| 鞘内注射NMDA拮抗吸入麻醉药的镇痛作用 |
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| 引用本文： | 杭黎华,戴体俊,曾因明. 鞘内注射NMDA拮抗吸入麻醉药的镇痛作用[J]. 中国药理学通报, 2005, 21(9): 1062-1065 |
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| 作者姓名： | 杭黎华 戴体俊 曾因明 |
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| 作者单位： | 徐州医学院江苏省麻醉学重点实验室,江苏,徐州,221002 |
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| 基金项目： | 国家自然科学基金，江苏省自然科学基金 |
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| 摘 要： | 目的探讨脊髓NMDA受体与吸入麻醉药安氟醚、异氟醚、七氟醚镇痛作用的关系。方法建立小鼠注射吸入麻醉药镇痛模型,用热板法和扭体法实验分别观察鞘内注射(it)不同剂量的NMDA对其痛阈的影响。结果NMDA2.5、5、10 ng it对清醒小鼠热板法痛阈(Pain threshold in hot-p late test,HPPT)和扭体次数无明显影响(P>0.05);NMDA2.5、5、10 ng it可剂量依赖性地减少安氟醚、异氟醚、七氟醚镇痛小鼠的HPPT(P<0.05)和增加扭体反应的次数(P<0.05)。结论脊髓的NMDA受体是吸入麻醉药安氟醚、异氟醚、七氟醚镇痛作用的重要靶位。
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| 关 键 词： | NMDA受体 吸入麻醉药 脊髓 镇痛 机制 |
| 文章编号： | 1001-1978（2005）09-1062-04 |
| 收稿时间： | 2005-01-17 |
| 修稿时间： | 2005-03-17 |
Effects of intrathecal injection of NMDA on the analgesia of inhalation anesthetics |
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| HANG Li-hua,DAI Ti-jun,ZENG Yin-ming. Effects of intrathecal injection of NMDA on the analgesia of inhalation anesthetics[J]. Chinese Pharmacological Bulletin, 2005, 21(9): 1062-1065 |
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| Authors: | HANG Li-hua DAI Ti-jun ZENG Yin-ming |
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| Abstract: | Aim To investigate the relationship between spinal cord NMDA receptors and the analgesic effects of enflurane,isoflurane and sevoflurane. Methods After having established the mice model of analgesia, we intrathecally injected different doses of (NMDA) and then observed the effects of pain thresholdusing hot-plate test and acetic acid-induced writhing test. Results Intrathecal NMDA 2.5,5,10 ng didn't affect the pain threshold in hot-plate test(HPPT) or writhing time in conscious mice(P>0.05);in contrast, intrathecal NMDA 2.5,5,10 ng could significantly and dose dependently decrease the HPPT(P<0.05) and increase writhing time(P<0.05) in the three inhalation anesthetics treated mice. Conclusion Spinal NMDA receptors may be important target for the analgesic effects of enflurane,isoflurane and sevoflurane. |
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| Keywords: | spinal cord NMDA receptors inhalation anesthetics analgesia mechanism |
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