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Matrine improves 17α-ethinyl estradiol-induced acute cholestasis in rats |
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| Authors: | Ying Zhao Desheng Zhai Hui He Junhua Liu Tingting Li Xijing Chen Hui Ji |
| Affiliation: | School of Pharmacy, China Pharmaceutical University, Nanjing,;School of Pharmacy, Xinxiang Medical University, Xinxiang, and;School of Public Health, Central South University, Changsha, China |
| Abstract: | Aim: To explore the effects of matrine (MT) on acute intrahepatic cholestasis induced by 17α-ethinyl estradiol (EE) in rats. Methods: Acute intrahepatic cholestasis in rats were induced by EE, and the effects of MT on acute intrahepatic cholestasis were explored and compared with ursodeoxycholic acid (UDCA) by serum biochemical determination and bile excretion experiments. Results: The serum biochemical and bile biochemical results indicated that MT and UDCA had notable hepatoprotective effects by counteracting cholestasis induced by EE. The bile flow and the bile excretion of glycocholic acid (GC, a substrate of bile salt export pump [Bsep]), ketoprofen glucuronide (KPG) and rhodamine 123 (Rh123, a substrate of multidrug resistance protein 1 [MDR1]) decreased by EE, were significantly improved after administration of MT. Conclusion: MT exhibited potential protection against EE-induced acute intrahepatic cholestasis. |
| Keywords: | bile excretion ethinyl estradiol intrahepatic cholestasis matrine |