| 多巴胺D3受体基因多态性与精神分裂症亚型及利培酮疗效相关性分析 |
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| 引用本文： | 吕路线,张红星,郭素芹,石玉中.多巴胺D3受体基因多态性与精神分裂症亚型及利培酮疗效相关性分析[J].上海精神医学,2005,17(2):99-101. |
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| 作者姓名： | 吕路线 张红星 郭素芹 石玉中 |
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| 作者单位： | 453003,河南新乡医学院第二附属医院;453003,河南新乡医学院第二附属医院;453003,河南新乡医学院第二附属医院;453003,河南新乡医学院第二附属医院 |
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| 摘 要： | 目的探讨多巴胺D3受体(dopamine D3 receptor,DRD3)基因第一外显子丝氨酸9甘氨酸(Ser9Gly)多态性与精神分裂症临床亚型、药物疗效的关联.方法 241 例汉族首发精神分裂症患者,采用限制性片段长度多态性(restriction fragment length polymorphism,RFLP)技术测定基因型.分析判断基因多态性与精神分裂症的临床亚型、药物疗效的关联. 结果精神分裂症各亚型Ser9Gly等位基因分布存在显著性差异(p <0.05).利培酮疗效不同的患者间Ser9Gly等位基因多态性均无显著性差异. 结论 DRD3受体基因第一外显子Ser9Gly多态性可能与精神分裂症亚型相关,而与患者对药物的反应不相关.
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| 关 键 词： | 精神分裂症 基因 多巴胺D3受体 限制性片段长度多态性 利培酮 |
Association between polymorphism in the dopamine D3 receptor gene and the sutypes of schizophrenia and efficacy of risperidone |
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| Lv Luxian,Zhang Hongxing,Guo Suqin,et al..Association between polymorphism in the dopamine D3 receptor gene and the sutypes of schizophrenia and efficacy of risperidone[J].Shanghai Archives of Psychiatry,2005,17(2):99-101. |
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| Authors: | Lv Luxian Zhang Hongxing Guo Suqin |
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| Institution: | Lv Luxian,Zhang Hongxing,Guo Suqin,et al.The Second Affilicated Hospital of XinXiang Medical College,Xinxiang 453003 |
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| Abstract: | Objective: To investigate the association between the dopamine D 3 receptor (DRD 3 )gene Ser9Gly polymorphism and the subtypes of schizophrenia and the efficacy of risperidone. Methods: DRD 3 gene Ser9Gly polymorphism were detected with polymorase chain reaction in 241 inpatients with schizophrenia. Results:Distribution of allele was significant different among different subtypes of schizophrenia(P <0.05). There were no difference of Ser9Gly gene polymorphism in different responders to risperidone. Conclusion:There is an association between the DRD 3 Ser9Gly gene polymorphism and the subtypes of schizophrenia. No association exists between the Ser9Gly polymorphism and the efficacy of risperidone. |
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| Keywords: | Schizophrenia Gene Dopamine D 3 receptor Restriction fragment length polymorphism Risperidone |
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