| 东乡族原发性高血压血管紧张素转换酶基因多态性 |
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| 引用本文： | 伊琳 顾远晖 周瑞霞 谢小冬. 东乡族原发性高血压血管紧张素转换酶基因多态性[J]. 兰州大学学报(医学版), 2007, 33(1): 48-50 |
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| 作者姓名： | 伊琳 顾远晖 周瑞霞 谢小冬 |
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| 作者单位： | 兰州大学,校医院;甘肃省人民医院,普外科,甘肃,兰州,730000;兰州大学,生命科学学院,甘肃,兰州,730000 |
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| 摘 要： | 目的 研究血管紧张素转化酶基因（ACE）单核苷酸多态性（SNP）与东乡族原发性高血压血脂的关系。方法 120例原发性高血压患者及102例正常人，用PCR及电泳分析法进行基因分型；分析各基因型与东乡族人群原发性高血压血脂水平的相关性。结果在东乡族高血压患者中，ACEI／D基因携带D等位基因患者的收缩压水平及高密度脂蛋白水平与Ⅱ基因型有显著差异，其中DD基因型者24个，ID基因型74个，Ⅱ基因型22个。收缩压水平分别为19．35±11、19．35±12、18．05±10kPa，P=0．012，高密度脂蛋白水平分别为1．14±0．2、1.3±=0.35、1．95±1．11mmol／L，P=0．010，而在正常对照组中则无此差异：结论 ACEI／D基因多态性D等位基凶与东乡族原发性高血压的高收缩压及较低水平的高密度脂蛋白相关。
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| 关 键 词： | 东乡族 原发性高血压 血管紧张素转化酶基因 单核苷酸多态性 血脂 |
| 文章编号： | 1000-2812（2007）01-0048-03 |
| 修稿时间： | 2006-12-17 |
Relationship between angiotensin-converting enzyme I/D polymorphisms and blood lipids in Dongxiang minority with essential hypertension |
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| YI Lin, Gu Yuan-hui, ZHOU Rui-xia, XIE Xiao-dong. Relationship between angiotensin-converting enzyme I/D polymorphisms and blood lipids in Dongxiang minority with essential hypertension[J]. Journal of Lanzhou University (Medical Sciences), 2007, 33(1): 48-50 |
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| Authors: | YI Lin Gu Yuan-hui ZHOU Rui-xia XIE Xiao-dong |
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| Abstract: | Objective To study the relationship between angiotensin-converting enzyme(ACE) I/D polymorphism and blood lipids in Dongxiang minority with essential hypertension.Methods 120 essential hypertension(EH)cases and 102 healthy controls were studied.Genotype of ACE I/D was conducted with PCR and agarose gel electrophoretic analysis.All statistical analyses were performed with SPSS for Windows.Results Association between genotype SBP and HDL in Dongxiang minority with essential hypertension but not in controls was found(P=0.012, 0.010,respectively).Conclusions D alleles related to SBP,HDL in Dongxiang minority with essential hypertension. |
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| Keywords: | Dongxiang minority essential hypertension angiotensin-converting enzyme singlenucleotide polymorphism blood lipid |
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