肾嫌色细胞癌的诊治（附4例报告）

目的 提高肾嫌色细胞癌的诊治水平。方法 回顾性分析4例肾嫌色细胞癌患者的临床资料。男3例，女1例，年龄34—76岁，平均52岁。结果 3例患者行肾癌根治术，1例行肾部分切除术。术后病理诊断为肾嫌色细胞癌，病理分期：pT1aNxMo 1例，pT1bNoMo3例。病理分级：G1 3例，G2 1例。免疫组织化学染色：CK8（低分子量细胞角蛋白）阳性，Vimentin（波型蛋白）阴性，Hale胶体铁阳性。随访4个月至8年，平均4年。4例患者均健在，无肿瘤复发或转移。结论 肾嫌色细胞癌是一种低度恶性的肾细胞癌，影像学检查对其诊断有重要帮助，确诊有赖于组织病理学检查，手术治疗后预后较好。

The diagnosis and treatment of renal chromophobe cell carcinoma (report of four cases)

Objective To improve the skills of diagnosis and treatment of renal chromophobe cell carcinoma(RCCC).Methods We retrospectively analyzed the clinical data of four cases with RCCC,including three males and one female,whose age ranged from 34 to 76 years,with a mean of 52 years.Results Three cases with RCCC underwent radical nephrectomies.One case underwent partial nephrectomy.The pathological examination confirmed the diagnosis of RCCC postoperation.The pathological TNM stage of RCCC was as follows: pT1a NxM0 in one case,and pT1bN0M0 in three cases.The pathological grade of RCCC was G1 in 3 cases and G2 in one case.Immunohistochemical stain was performed.There were positive staining for CK8(cytokeratin subtypes),negative for Vimentin and positive for Hale's colloidal iron in the carcinoma cells.All four cases were followed up.The duration of follow-up was from four months to eight years(average four years).All four cases had been surviving and there had been no recurrences or metastases during postoperative follow-up.Conclusion RCCC is a distinct subtype of renal cell carcinoma that exhibits low-degree malignancy.The radiologic imaging plays an important role in diagnosis of RCCC.The definite diagnosis depends on histopathologic examination.The prognosis is more favorable than the other subtypes of renal cell carcinoma after operation.