Spectrophotometric determination of etidocaine in pharmaceutical (dental) formulation |
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| Authors: | Silva Nelson Schapoval Elfrides E S |
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| Affiliation: | 1. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Ipiranga, 2752, Porto Alegre, R/S, CEP 90160-000 Porto Alegre, Brazil;2. Departamento de Produção e Controle de Qualidade de Medicamentos, Faculdade de Farmácia, UFRGS, Av. Ipiranga, 2752, 4° Andar, Sala 402, Brazil;1. Candidate for Master''s Degree, Department of Periodontology, National Clinical Research Center for Oral Diseases, School of Stomatology, Fourth Military Medical University, Xi''an, China;2. Candidate for Master''s Degree, Department of Periodontology, National Clinical Research Center for Oral Diseases, School of Stomatology, Fourth Military Medical University, Xi''an, China;3. Candidate for Master''s Degree, Department of Periodontology, National Clinical Research Center for Oral Diseases, School of Stomatology, Fourth Military Medical University, Xi''an, China;4. Resident, Department of Periodontology, National Clinical Research Center for Oral Diseases, School of Stomatology, Fourth Military Medical University, Xi''an, China;6. Resident, Department of Periodontology, National Clinical Research Center for Oral Diseases, School of Stomatology, Fourth Military Medical University, Xi''an, China;5. Head and Professor, Department of Periodontology, National Clinical Research Center for Oral Diseases, School of Stomatology, Fourth Military Medical University, Xi''an, China;1. Department of Physics, Lovely Professional University, Phagwara-144411, Punjab, India;2. Department of Physics, Faculty of Science, Federal University Dutse, P.M.B. 7156, Dutse, Jigawa state, Nigeria;3. SRM Research Institute, SRM University, Kattankulathur, Chennai-603203, Tamil Nadu, India;4. Department of Chemistry, Lovely Professional University, Phagwara-144411, Punjab, India;5. Department of Chemistry, Guru Nanak Dev University, Amritsar-143005, India;1. Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore;2. Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore;1. Department of Clinical Laboratory, Iwate Health Service Association, Morioka, Japan;2. Division of Cardiology, Department of Internal Medicine, Iwate Health Service Association, Morioka, Japan;3. Department of Internal Medicine, Morioka Tsunagi Onsen Hospital, Morioka, Japan;4. Department of Internal Medicine, Iwate Medical University, Morioka, Japan;1. Fishery Machinery and Instrument Research Institute of Chinese Academy of Fishery Sciences, Shanghai, 200092, China;2. Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration, East China Normal University, Shanghai, 200241, China;3. Shanghai Chenshan Plant Science Research Centre, Chinese Academy of Sciences, Shanghai Chenshan Botanical Garden, Shanghai, 201602, China;4. School of Ecology and Environment, Yellow River Conservancy Technical Institute, Kaifeng, 475004, China |
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| Abstract: | A spectrophotometric method was developed for the determination of etidocaine hydrochloride (EH) in injectable pharmaceutical preparation. The proposal of this work was to develop a rapid, simple, inexpensive, precise and accurate visible spectrophotometric method. The method is based on the formation of the ion-pair complex by the EH reaction with bromocresol green in the pH 4.6 which after chloroform extraction gives a yellow color that in basic medium change to blue color and exhibits a maximum absorbance at 625 nm. The calibration graph was linear over the range 2.0-6.0 microg ml(-1) EH calculated on the final yellow solution. The R.S.D. of the slope of the four lines was 0.73%. This method can be applied to injectable pharmaceutical preparation dosage studied. |
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