| 细胞周期蛋白在喉癌组织中的表达及意义 |
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| 引用本文： | 刘馨莲,殷舞,李淑蓉,孙静.细胞周期蛋白在喉癌组织中的表达及意义[J].实用癌症杂志,2011,26(6):585-587,595. |
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| 作者姓名： | 刘馨莲 殷舞 李淑蓉 孙静 |
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| 作者单位： | 1. 成都医学院,610083
2. 广西壮族自治区人民医院,530021 |
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| 摘 要： | 目的探讨喉癌组织中细胞周期蛋白（Cyclin D1、Cyclin A、Cyclin B1、Cyclin E）的表达规律及其与喉癌临床病理参数的关系。方法采用免疫组化技术,检测Cyclin D1、Cyclin A、Cyclin B1、Cyclin E在67例喉癌组织和32例癌旁正常组织中的表达情况。结果 Cyclin D1、Cyclin A、Cyclin B1、Cyclin E在癌旁正常组织中呈低表达。随着喉癌分化程度的降低,Cyclin D1、Cyclin A、Cyclin B1、Cyclin E表达阳性率明显升高,高分化者、中分化者与低分化者比较有显著性差异（P〈0.05）。结论通过免疫组织化学法分析细胞周期的数据,有利于肿瘤分级,且细胞周期数据与预后相关。
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| 关 键 词： | 喉癌 Cyclin D1蛋白 Cyclin A蛋白 Cyclin B1蛋白 Cyclin E蛋白 |
Expression and Significance of Cyclins in Laryngeal Carcinomas |
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| LIU Xin-lian,YIN Wu,LI Shu-rong,et al..Expression and Significance of Cyclins in Laryngeal Carcinomas[J].The Practical Journal of Cancer,2011,26(6):585-587,595. |
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| Authors: | LIU Xin-lian YIN Wu LI Shu-rong |
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| Institution: | LIU Xin-lian,YIN Wu,LI Shu-rong,et al.Department of Pathology,Chengdu Medical College,Chengdu,610083 |
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| Abstract: | Objective To investigate the expression and significance of Cyclin D1,Cyclin A,Cyclin B1 and Cyclin E in laryngeal carcinomas,and study the correlation between parameters and clinicopathological features.Methods Expression of Cyclin D1,Cyclin A,Cyclin B1 and Cyclin E were analyzed by immunohistochemistry staining in 67 cases of laryngeal carcinomas and 32 peri-cancer normal larynx tissues.Results Cyclin D1,Cyclin A,Cyclin B1 and Cyclin E were low Expressed in peri-cancer normal larynx tissues.With the decre... |
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| Keywords: | Laryngeal carcinoma Cyclin D1 protein Cyclin A protein Cyclin B1 protein Cyclin E protein |
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