| 葡萄糖转运蛋白1在乳腺癌组织中的表达及与其预后的关系 |
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| 引用本文： | 沈春燕,穆海玉,佟仲生.葡萄糖转运蛋白1在乳腺癌组织中的表达及与其预后的关系[J].实用癌症杂志,2011,26(6):575-577,584. |
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| 作者姓名： | 沈春燕 穆海玉 佟仲生 |
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| 作者单位： | 1. 武警医学院附属医院肿瘤科,300162
2. 天津医科大学附属肿瘤医院乳腺肿瘤内科,天津市肿瘤防治重点实验室,300060 |
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| 摘 要： | 目的探讨葡萄糖转运蛋白1（glucose transporter 1,GLUT-1）在乳腺癌组织中的表达及与其预后的关系。方法采用免疫组织化学SABC法,检测81例乳腺癌及20例乳腺纤维瘤组织中GLUT-1表达情况;观察GLUT-1表达与乳腺癌组织临床病理因素及预后的关系。结果乳腺癌中GLUT-1阳性表达率为61.7%（50/81）,而乳腺纤维瘤组织中未检测到GLUT-1阳性表达（P〈0.001）。GLUT-1表达与淋巴结转移数目及肿瘤有无复发、转移显著相关（P〈0.05）,而与雌孕激素受体表达和肿瘤大小无显著相关性（P〉0.05）。GLUT-1阳性组和阴性组无复发生存时间分别为（48.56±3.35）个月和（66.79±4.50）个月,具有统计学差异（P〈0.05）。结论 GLUT-1高表达提示肿瘤具有较强浸润生物学行为,GLUT-1表达与乳腺癌的预后密切相关。
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| 关 键 词： | 乳腺肿瘤 葡萄糖转运蛋白1 预后 |
GLUT-1 Expression and its Correlation with Prognosis in Human Breast Carcinoma |
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| SHEN Chun-yan,MU Hai-yu,TONG Zhong-sheng.GLUT-1 Expression and its Correlation with Prognosis in Human Breast Carcinoma[J].The Practical Journal of Cancer,2011,26(6):575-577,584. |
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| Authors: | SHEN Chun-yan MU Hai-yu TONG Zhong-sheng |
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| Institution: | SHEN Chun-yan,MU Hai-yu,TONG Zhong-sheng.Department of Medical Oncology,the Affiliated Hospital of Armed police for Medical College,Tianjin,300162 |
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| Abstract: | Objective To study the expression of glucose transporter 1(GLUT-1) in human breast cancer and its relationship with prognosis.Methods Inununohistoehemistry(Strept Avidin-Biotin-enzyme Complex) was applied to measure the expression of GLUT-1 in 81 cases of breast carcinoma and 20 cases of breast fibroadenoma.The GLUT-1 expression was correlated with clinical factors and prognosis of breast carcinoma.Results The total positive rate of GLUT-1 in breast carcinoma was 61.7%(50/81),and it was not found expressing... |
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| Keywords: | Breast carcinoma Glucose transporter 1(GLUT-1) Prognosis |
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