| 多西他赛联合奥沙利铂治疗晚期胃癌的临床观察 |
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| 引用本文： | 李晓琴,姬发祥,林明哲,马金华,李豪.多西他赛联合奥沙利铂治疗晚期胃癌的临床观察[J].现代肿瘤医学,2011,19(12):2498-2500. |
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| 作者姓名： | 李晓琴 姬发祥 林明哲 马金华 李豪 |
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| 作者单位： | 青海大学附属肿瘤医院肿瘤内科,青海,西宁,810001 |
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| 摘 要： | 目的:观察多西他赛、奥沙利铂联合方案治疗晚期胃癌的疗效和安全性。方法:经病理证实的晚期胃癌患者26例,采用多西他赛联合奥沙利铂,治疗2-4个周期。按照RECIST标准和WHO毒性反应分级标准,分别评价疗效和毒性。结果:26例晚期胃癌患者中,获得CR 0例,PR 8例,SD 12例,PD 6例,总有效率30.8%,疾病控制率76.9%;中位TTP 6.3个月,中位总生存10.7个月,毒性反应主要为血液学毒性、消化道反应和神经毒性等。结论:多西他赛、奥沙利铂联合方案治疗晚期胃癌的客观疗效高,安全性好。
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| 关 键 词： | 晚期胃癌 多西他赛 奥沙利铂 |
Docetaxel plus oxaliplatin in treatment of advanced gastric cancer: a clinical observation |
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| LI Xiaoqin,JI Faxiang,LIN Mingzhe,MA Jinhua,LI Hao.Docetaxel plus oxaliplatin in treatment of advanced gastric cancer: a clinical observation[J].Journal of Modern Oncology,2011,19(12):2498-2500. |
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| Authors: | LI Xiaoqin JI Faxiang LIN Mingzhe MA Jinhua LI Hao |
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| Institution: | LI Xiaoqin,JI Faxiang,LIN Mingzhe,MA Jinhua,LI Hao Department of Oncology,the Affiliated Hospital of Qinghai Medical University,Qinghai Xining 810001,China |
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| Abstract: | Objective:To observe the efficacy and safety of docetaxel combined with oxaliplatin in the treatment of advanced gastric cancer.Methods: Twenty six patients with advanced gastric cancer were treated with docetaxel and oxaliplatin 2-4 cycle of treatment.According to RECIST criteria and WHO toxicity classification standard,the efficacy and toxicity were evaluated.Results: Among 26 cases,there were CR 0,PR 8,SD 12,PD 6,Overall response rate was 30.8%,disease control rate was 76.9%;median TTP was 6.3 months,med... |
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| Keywords: | advanced gastric cancer docetaxel oxaliplatin |
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