| FLAG方案与CAG方案治疗复发、难治性急性髓系白血病的疗效比较 |
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| 引用本文： | 李佳,胡荣,廖爱军,杨莹,杨威,刘卓刚. FLAG方案与CAG方案治疗复发、难治性急性髓系白血病的疗效比较[J]. 现代肿瘤医学, 2011, 19(12): 2530-2533. DOI: 10.3969/j.issn.1672-4992.2011.12.57 |
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| 作者姓名： | 李佳 胡荣 廖爱军 杨莹 杨威 刘卓刚 |
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| 作者单位： | 中国医科大学附属盛京医院血液科,辽宁,沈阳,110004 |
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| 摘 要： | 目的:评价并比较FLAG方案与CAG方案治疗复发、难治性急性髓系白血病(acute myeloid leukemi-a,AML)的疗效及安全性。方法:将2004年1月至2011年3月于我院接受化疗的复发、难治性AML患者74例,按治疗方案分成FLAG组和CAG组,对2组的疗效及不良反应进行分析比较。结果:FLAG组完全缓解率(CR)为61.5%,总有效率为76.9%;CAG组CR为35.4%,总有效率为50%,组间比较差异有显著性意义(P<0.05)。原发难治AML、复发性AML、M1型、M2型、M5型及由骨髓增生异常综合征(myelody splastic syn-drome,MDS)转化而来的复发、难治性AML的CR率和总有效率,FLAG组均高于CAG组,组间比较差异有显著性意义(P均<0.05)。2组的血液学不良反应主要是骨髓抑制,非血液学不良反应较少。结论:CAG方案和FLAG方案均为复发、难治性AML的有效治疗方案,但FLAG方案CR率和总有效率高,不良反应可耐受,可进一步扩大临床应用。
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| 关 键 词： | FLAG方案 CAG方案 复发性急性髓系白血病 难治性急性髓系白血病 疗效 不良反应 |
Comparison of FLAG regimen with CAG regimen for refractory or relapsed acute myeloid leukemia |
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| LI Jia,HU Rong,LIAO Aijun,YANG Ying,YANG Wei,LIU Zhuogang. Comparison of FLAG regimen with CAG regimen for refractory or relapsed acute myeloid leukemia[J]. Journal of Modern Oncology, 2011, 19(12): 2530-2533. DOI: 10.3969/j.issn.1672-4992.2011.12.57 |
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| Authors: | LI Jia HU Rong LIAO Aijun YANG Ying YANG Wei LIU Zhuogang |
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| Affiliation: | LI Jia,HU Rong,LIAO Aijun,YANG Ying,YANG Wei,LIU Zhuogang Department of Hematology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China |
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| Abstract: | Objective:To investigate the efficacy and safety of FLAG and CAG regimen for refractory or released acute myeloid leukemia(AML).Methods: Seventy-four patients with refractory or released AML in our hospital were divided into FLAG group and CAG group.The efficacy and toxicities were analyzed and compared between the two groups.Results: The complete remission rate(CR) was 61.5% and the overall response(OR) rate was 76.9% in FLAG group.The CR rate was 35.4% and the OR rate was 50% in CAG group.For the patients... |
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| Keywords: | FLAG regimen CAG regimen relapsed AML refractory AML efficacy toxicities |
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