| NKT细胞和HIV感染 |
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| 引用本文： | 黄孝军,侯炜. NKT细胞和HIV感染[J]. 武汉大学学报(医学版), 2009, 30(4): 556-560 |
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| 作者姓名： | 黄孝军 侯炜 |
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| 作者单位： | 武汉大学医学病毒学研究所/病毒学国家重点实验室,湖北,武汉430071;湖北民族学院,湖北,恩施,445000;武汉大学医学病毒学研究所/病毒学国家重点实验室,湖北,武汉430071 |
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| 摘 要： | NKT细胞是一群表达半不变量T细胞受体(TCR)的淋巴细胞亚群,它识别由非多态性MHC-Ⅰ类分子CD1d呈递的糖脂。NKT细胞有免疫调节功能,抵抗自身抗原和病原体。最近研究发现,NKT细胞是HIV-1感染的靶细胞之一,且在HIV感染者体内选择性减少。本文着重讨论上述发现的机制、后果以及HIV-1感染治疗前景。
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| 关 键 词： | NKT细胞 HIV-1感染 细胞因子 |
NKT Cells and HIV Infection |
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| HUANG Xiaojun,HOU Wei. NKT Cells and HIV Infection[J]. Medical Journal of Wuhan University, 2009, 30(4): 556-560 |
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| Authors: | HUANG Xiaojun HOU Wei |
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| Affiliation: | HUANG Xiaojun1,2,HOU Wei11State Key Laboratory of Virology & Institute of Medical Virology,Wuhan University,Wuhan 430071,China2Hubei University for Nationalities,Enshi 445000,Hubei,China |
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| Abstract: | Natural killer T(NKT) cells are a subset of lymphocytes that express a semi-invariant T cell receptor(TCR) that recognizes glycolipids presented by the non-polymorphic MHC class Ⅰ-like molecule CD1d.NKT cells regulate a wide variety of immune functions against auto-antigens and pathogens.Recently,it was shown that NKT cells are targeted by HIV-1 and selectively lost in HIV-infected individuals.This review will focus on the mechanisms,consequences and therapeutic implications of these findings. |
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| Keywords: | Natural Killer T Cell HIV Infection Cytokine |
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