| 谷氨酸和一氧化氮在新生儿缺氧缺血性脑病发病中的作用 |
| |
| 引用本文： | 刘晓红,刘晓光,刘皖君.谷氨酸和一氧化氮在新生儿缺氧缺血性脑病发病中的作用[J].中华围产医学杂志,2000,3(2):89-91. |
| |
| 作者姓名： | 刘晓红 刘晓光 刘皖君 |
| |
| 作者单位： | 1. 430016,武汉市儿童医院新生儿科
2. 同济医科大学附属医院儿科 |
| |
| 摘 要： | 目的 研究新生儿缺氧缺血性脑病 (HIE)患儿脑脊液谷氨酸和一氧化氮 (NO)水平变化 ,探讨二者在新生儿 HIE中的作用及相互关系。 方法 对 2 4例新生儿 HIE脑脊液谷氨酸和 NO水平进行检测 ,并与 8例对照组比较。 结果 重度 HIE组脑脊液谷氨酸和 NO水平明显高于对照组(分别为 92± 42和 148.7± 5 .4,高于 45± 5和 83.3± 2 7.5 )μmol/ L ],谷氨酸和 NO水平呈显著正相关(r=0 .6 2 ,P<0 .0 1)。 结论 谷氨酸和 NO在新生儿 HIE的发生和发展过程中具有重要意义。
|
| 关 键 词： | 一氧化氮 谷氨酸 新生儿 缺氧缺血性脑病 |
| 修稿时间： | 1999-03-15 |
Role of Glutamate and Nitric Oxide in Newborn Infants with Hypoxic-Ischemic Encephalopathy |
| |
| LIU Xiaohong,LIU Xiaoguang,LIU Wanjun.Role of Glutamate and Nitric Oxide in Newborn Infants with Hypoxic-Ischemic Encephalopathy[J].Chinese Journal of Perinatal Medicine,2000,3(2):89-91. |
| |
| Authors: | LIU Xiaohong LIU Xiaoguang LIU Wanjun |
| |
| Abstract: | Objective To study the change of cerebro spinal fluid(CSF) glutamate and nitric oxide (NO) levels in neonatal hypoxic ischemic encephalopathy(HIE), and explore the role of glutamate and NO in the pathogenesis of neonatal HIE and relationship between each other. Methods CSF glutamate and NO levels were studied in 24 newborn infants with HIE, and 8 neonates served as control. Results CSF glutamate and NO levels were much higher in newborn infants with the moderate and severe HIE when compared with the control group and mild HIE; glutamate levels were significantly related to NO levels. Conclusion Glutamate and NO are significant to the pathogenesis of neonatal HIE. |
| |
| Keywords: | Infant newborn Glutamic acid Nitric oxide Cerebral ischemia Cerebral anoxia |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
