Anatomical and functional impact of verteporfin shortage in patients with chronic central serous chorioretinopathy |
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| Affiliation: | 1. Department of Ophthalmology, Hospital Clínico San Carlos. Instituto de Investigación Sanitaria (IdISSC). Madrid, Spain;2. Centro Internacional de Oftalmología Avanzada, Madrid, Spain;3. Department of Ophthalmology, Bellvitge University Hospital, L''Hospitalet de Llobregat, Barcelona, Spain;1. Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia;2. Department of General Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia;3. Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia;4. Department of Oral and Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Taif University, Taif, Saudi Arabia;1. Department of ophthalmology, Chifeng Chaoju Eye Hospital, Chifeng, 024000, China;2. Department of ophthalmology, Datong Chaoju Ankang Eye Hospital, Datong, 037006, China;3. Department of ophthalmology, Inner Mongolia Chaoju Eye Hospital, Hohhot, 010050, China;4. Department of ophthalmology, Hohhot Chaoju Eye Hospital, Hohhot, 010010, China |
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| Abstract: | BackgroundTo describe the functional and anatomical impact that the worldwide shortage of verteporfin has had on patients diagnosed with chronic central serous chorioretinopathy (cCSCR) whose treatment with photodynamic therapy (PDT) had to be delayed.MethodsProspective observational study. Patients were divided into two groups based on the time interval since PDT had been indicated: groups 1 and 2, with waiting times of less and more than 9 months respectively. Best corrected visual acuity (BCVA), the maximum height of the subretinal fluid (MSRF) and subfoveal choroidal thickness (SFCT) at the baseline visit and the last visit were compared.Results49 eyes of 48 patients with cCSCR were included. The mean waiting time for PDT was 9.0 ±3.8 months. The mean BCVA was 69.0 ±17.1 letters and 68.9 ±16.4 letters for the baseline and last visit respectively, showing no difference (p= 0.958). Although there was no difference in the mean global BCVA, 15 eyes (30.5%) showed a deterioration of ≥5 letters, including 7 eyes (14%) with a decrease of ≥10 letters. Mean MSRF height was 151.4 ±97.2 μm and 98.2 ±83.1 μm for the baseline and last visit respectively (p= 0.005), persisting in 74.5% of the eyes.ConclusionNo significant impact was observed in the BCVA in cCSCR due to the shortage of verteporfin. However, one-third of patients had BCVA loss. There was a significant spontaneous decrease in MSRF, but it persisted in the majority of the patients, still susceptible to PDT. |
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