Association between macular and papillary vessel density by optical coherence tomography angiography in a large healthy population |
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| Institution: | 1. Department of Ophthalmology, Hospital Clínico San Carlos. Instituto de Investigación Sanitaria (IdISSC). OFTARED. Madrid, Spain;2. Centro Internacional de Oftalmología Avanzada, Madrid, Spain;3. Department of Ophthalmology, Hospital 12 de Octubre, Madrid, Spain;4. Department of Ophthalmology, Hospital Puerta de Hierro Majadahonda, Madrid, Spain;5. Department of Ophthalmology, Universidad de Extremadura, Badajoz, Spain;1. Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA;2. Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA;3. Department of Surgery, City of Hope National Medical Center, Duarte, CA;1. Center of Biophotonics, School of Dentistry, Federal University of Bahia – UFBA, Av. Araújo Pinho, 62, Canela, Salvador, BA CEP: 40110-150, Brazil;2. Laboratory of Biotechnology and Ecology of Microorganisms, Institute of Health Science, Federal University of Bahia, Reitor Miguel Calmon Ave, S/N, Salvador, BA CEP:40110-100, Brazil;3. Organic Semiconductor Centre, SUPA, School of Physics & Astronomy, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9SS, UK;4. Department of Biology, Feira de Santana State University, Feira de Santa, BA 44036-900, Brazil;5. School of Dentistry, Ruy Barbosa Wyden University Center University (UniRuy Wyden), Av. Luís Viana Filho, 3172 - Paralela, Salvador - BA CEP: 41720-200, Brazil;1. Department of Restorative Dentistry, School of Dentistry, Araraquara, São Paulo State University – UNESP, Araraquara, SP, Brazil;2. Department of Dentistry, Federal University of Juiz de Fora (UFJF), Campus Governador Valadares, Governador Valadares, MG, Brazil;3. School of Dentistry, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil;1. Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, 730030, China;2. Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, Gansu, 730030, China;3. Key Laboratory of System Tumors of Gansu Province, Lanzhou, Gansu, 730030, China |
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| Abstract: | PurposeTo provide a normative data set of the relationship between macular and papillary vessel density (VD) using swept-source optical coherence tomography angiography (SS-OCTA) in a large healthy population.MethodsCross-sectional study conducted on 346 right eyes of healthy subjects. Macular and papillary SS-OCTA VD measurements of the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) in the central area and the four quadrants were obtained. Correlations between macular and papillary VD among different quadrants were assessed.ResultsThe mean participant age was 37.7 ± 19.8 years (range 5–83); 59% were women. No correlation was detected neither for the global SCP (R = 0.050; P = 0.040), DCP (R = -0.056; P = 0.038) nor CC (R = 0.102; P < 0.001) between macular and papillary VD. In a subanalysis, there was also no correlation in any of the quadrants studied (R ≤ 0.180; P < 0.001). In a subgroup of 45 left eyes, there was no correlation in the different plexus and layers studied between macular and papillary vasculature. No differences in SCP, DCP and CC were found according to gender, age or axial length in the relationship between macular and papillary VD.ConclusionThere is no association between macular and papillary VD neither in the SCP, DCP or CC in any of the regions studied. Hence, macular and optic nerve head vascularization should be investigated separately to identify which structure is more relevant in each disease. |
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