Predictive value of perioperative peripheral blood cells counts for bacteremia and 90-day mortality in severe burn patients |
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| Affiliation: | 1. Department of Anesthesiology, the First Affiliated Hospital of Sun Yat-sen University, China;2. Department of Anesthesiology, the Dongguan People''s Hospital, China;3. Department of Anesthesiology, Zhongshan People''s Hospital, China;1. Healing Foundation Centre for Burns Research, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK;2. University of Birmingham, Edgbaston, Birmingham B15 2TT, UK;1. Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States;2. North Carolina Jaycee Burn Center, Chapel Hill, NC, United States;3. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States;4. Division of Adult Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States;1. Université Paris Descartes, Paris Sorbonne Cité, 75006 Paris, France;2. Service de Chirurgie Générale, Plastique et Ambulatoire, AP-HP, Hôpitaux Universitaires Paris Centre, Hôpital Cochin, 75014 Paris, France;1. Université Paris Descartes, Paris Sorbonne Cité, 75006 Paris, France;2. Unité de Biostatistique et Epidémiologie, AP-HP, Hôpitaux Universitaires Paris Centre, Hôpital Hôtel-Dieu, 75004 Paris, France;1. Novant Health New Hanover Regional Medical Center, Wilmington, NC, United States;2. Spartanburg Regional Healthcare System, Spartanburg, SC, United States;3. Loyola Medicine, Maywood, IL, United States;1. Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA;2. Department of Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon;1. Physiotherapy Department, Royal Brisbane and Women’s Hospital, Brisbane, QLD 4029, Australia;2. Professor Stuart Pegg Adult Burn Centre, Royal Brisbane and Women’s Hospital, Herston, Brisbane, QLD 4029, Australia;3. Physiotherapy Department, Griffith University, Brisbane, QLD 4222, Australia |
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| Abstract: | ObjectiveBurn bacteremia is related to immune barrier damage, but whether the level of circulating immune cells predicts outcomes in severe burns is still not clear. This study aimed to explore the predictive value of perioperative blood cells of the first surgery after burn for bacteremia and 90-day death.MethodsData from severe burn patients treated at the First Affiliated Hospital of Sun Yat-sen University from 2011 to 2020 were retrospectively analyzed. Data on monocytes (M), lymphocytes (L), white blood cell-to-platelet ratio (WPR), neutrophil-to-lymphocyte ratio (NLR) in peripheral blood and changes in temperature (T-37) were collected at one day before(X0), the first day after (X1) and the third day after (X3) the primary surgery.Univariate and multivariate logistic regression were used to identify the independent risk factors of bacteremia and death within 90 days, which were used to establish the risk prediction models (xbac and x90d-m) in severely burned patients. Severe burn cases from two other burn centers were selected to verify the prediction models.ResultsWe analyzed 169 severe burn cases in the training dataset, with a 90-day mortality of 21.3% (36/169); 56 (33.1%) patients experienced burn bacteremia. Higher M0, WPR0, NLR0, NLR3, T3–37, ∆M (M0-M3) and lower M3, L3 were associated with higher risk of bacteremia (P < 0.05). Multivariate regression analysis showed that SOFA0, WPR0, M3, and T3–37 were independently associated with bacteremia. The prediction model for bacteremia Xbac = 0.1809 × SOFA0 + 6.532 × WPR0–1.171 × M3 + 0.6987 × T3–37- 2.297. TBSAB, SOFA0, and ∆M (M0-M3) were independently correlated with 90-day mortality. The risk prediction model X90d-m= 0.055 × TBSAB + 0.301 ×SOFA0 + 1.508 × ∆M - 7.196. External validation suggested that the specificity, sensitivity and AUC of the prediction model Xbac was 90.7%, 62.5% and 0.797, respectively; of the prediction model X90d-m was 69.2%, 90.0% and 0.873, respectively.ConclusionPeripheral M3, WPR0 and ∆M (M0-M3) during the primary surgery has reasonable predictive ability for bacteremia and 90-day mortality in severe burn patients, which could inform clinical antimicrobial judgment and prognostication. |
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| Keywords: | Burn Bacteremia Monocyte 90-day mortality Predictive value |
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