Choroidal vascularity index in adult patients with familial meditteranean fever |
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| Affiliation: | 1. Ministry of Health Ankara City Hospital, Ophthalmology Clinic, Ankara, Turkey;2. Ministry of Health Ankara City Hospital, Rheumatology Clinic, Ankara, Turkey;3. Ministry of Health Ankara City Hospital, Ophthalmology Clinic, Yıldırım Beyazıt University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey;1. MIREA - Russian Technological University, Pr. Vernadskogo, 78, Moscow, 119454, Russia;2. N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygina 4, Moscow, 119991, Russia;3. N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow, 119991, Russia;1. Department of Applied Electronics and Instrumentation Engineering, Haldia Institute of Technology, Haldia, West Bengal, India;2. Department of Applied Electronics and Instrumentation Engineering, Heritage Institute of Technology, Kolkata, West Bengal, India;3. Department of Applied Physics, University of Calcutta, Kolkata, West Bengal, India;1. Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia;2. Department of General Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia;3. Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia;4. Department of Oral and Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Taif University, Taif, Saudi Arabia;1. Laboratory of Immunology and Molecular Biology, Health Sciences Institute, Universidade Federal da Bahia, Salvador, Bahia State 40110-100, Brazil;2. Bioinorganic and Porphyrinoid Materials Laboratory, Department of Chemistry, Universidade Federal de Santa Maria, Rio Grande do Sul State, Santa Maria 97105-900, Brazil;3. Laboratory of Oral Biochemistry, Health Sciences Institute, Universidade Federal da Bahia, Salvador, Bahia State 40110-100, Brazil;4. Coulomb Electrostatic and Mechanochemistry Laboratory, Universidade Federal de Santa Maria, Rio Grande do Sul State, Santa Maria 97105-900, Brazil;5. Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais State 31270-901, Brazil |
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| Abstract: | PurposeThis study aimed to evaluate choroidal vascular status by the choroidal vascularity index (CVI) in adult patients with familial Mediterranean fever (FMF) in remission period.Materials-methods86 patients diagnosed with FMF and 54 healthy controls were recruited in this study. Retinal, ganglion cell complex and peripapillary retinal nerve fibre layer thicknesses were obtained using Spectralis domain-optical coherence (SD-OCT) tomography. Choroid images were obtained with the enhanced depth imaging mode of SD-OCT, and binarization was applied to the images using ImageJ software. CVI was described as the proportion of the luminal area to the total choroidal area. Blood-derived inflammation markers were calculated by the complete blood count.ResultsThe subfoveal choroidal thickness and nasal and temporal directions from fovea centralis at 500 μm, 1000 μm and 1500 μm were reduced in patients with FMF in comparison to healthy controls (p<0.001, each comparison). CVI was significantly decreased in patients with FMF compared to controls (62.28±2.2 and 64.79±4.3, p<0.001).ConclusionWe concluded that the choroidal vasculature structure may be affected prior to retinal changes in patients with FMF. |
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| Keywords: | OCT |
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