Impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum |
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Authors: | David M Gershenson Charlotte C Sun Kwong-Kwok Wong |
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Institution: | 1.Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA |
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Abstract: | Background: Low-grade serous carcinoma of the ovary or peritoneum is a distinct, well- recognized histologic subtype characterized by young age at diagnosis, relative chemoresistance, and prolonged overall survival. Common mutations reported to be found within this subtype include KRAS and BRAF.Methods: Using clinical information of patients from our IRB-approved registry and tissue from a subset of these patients, we performed mutational analysis for KRAS and BRAF using the direct Sanger sequencing technique and correlated findings with the clinical outcome, overall survival (OS).Results: In 79 cases, patients with KRAS or BRAF mutations (n=21) had a significantly better OS than those with wild-type KRAS or BRAF (n=58) (106.7 months (95% CI, 50.6, 162.9) vs 66.8 months (95% CI, 43.6, 90.0)), respectively (P=0.018).Conclusions: Mutational status appears to be a potential prognostic factor in low-grade serous carcinoma of the ovary or peritoneum. |
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Keywords: | ovarian cancer low-grade serous carcinoma KRAS BRAF |
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