Optical coherence tomography angiography findings in transfusion-dependent beta-thalassemia patients with and without splenectomy |
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| Institution: | 1. Transfusion Center, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkiye;2. Department of Hematology, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey;3. Department of Ophthalmology, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey;4. Department of General Surgery, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey;5. Department of Hematology, Kolan Hospital Group, Sisli Kolan International, Istanbul, Turkey;1. Center of Biophotonics, School of Dentistry, Federal University of Bahia – UFBA, Av. Araújo Pinho, 62, Canela, Salvador, BA CEP: 40110-150, Brazil;2. Laboratory of Biotechnology and Ecology of Microorganisms, Institute of Health Science, Federal University of Bahia, Reitor Miguel Calmon Ave, S/N, Salvador, BA CEP:40110-100, Brazil;3. Organic Semiconductor Centre, SUPA, School of Physics & Astronomy, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9SS, UK;4. Department of Biology, Feira de Santana State University, Feira de Santa, BA 44036-900, Brazil;5. School of Dentistry, Ruy Barbosa Wyden University Center University (UniRuy Wyden), Av. Luís Viana Filho, 3172 - Paralela, Salvador - BA CEP: 41720-200, Brazil;1. Department of Ophthalmology, Mardin Training and Research Hospital. Mardin, Turkey;2. Department of Ophthalmology, Başakşehir çam ve sakura city hospital. Istanbul, Turkey;1. Department of Restorative Dentistry, School of Dentistry, Araraquara, São Paulo State University – UNESP, Araraquara, SP, Brazil;2. Department of Dentistry, Federal University of Juiz de Fora (UFJF), Campus Governador Valadares, Governador Valadares, MG, Brazil;3. School of Dentistry, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil;1. Ankara City Hospital, Department of Ophthalmology, Ankara, Turkey;2. University of Health Sciences, Ankara City Hospital, Department of Ophthalmology, Ankara, Turkey;1. Department of Restorative Dentistry, School of Dentistry, University of São Paulo, São Paulo, Brazil;2. Department of Restorative Dentistry, School of Dentistry, São Paulo State University, São José dos Campos, Brazil;3. Brugnera and Zanin Institute, São Paulo, Brazil |
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| Abstract: | BackgroundOcular involvement is common in transfusion-dependent beta-thalassemia (TDβ-T) patients. We aimed to investigate the effect of splenectomy on optical coherence tomography angiography (OCTA) findings in TDβ-T patients.MethodsThe study is a prospective cross-sectional study. A total of 45 eyes of 23 patients with splenectomy (34.04±8.83 years), 18 eyes of 9 patients without splenectomy (27.44±5.43 years), and 54 eyes of 27 controls (33.22±6.44 years) were included. Vessel density in superficial capillary plexus, deep capillary plexus and radial peripapillary capillary, foveal avascular zone, choriocapillaris flow area, choroidal and retinal thickness detected by OCTA were evaluated. p < 0.05 was considered significant.ResultsVessel density of superficial capillary plexus and deep capillary plexus were similar in patients with and without splenectomy, and controls. Choriocapillaris flow area was significantly decreased in patients with splenectomy than that in those without splenectomy and controls (2.02±0.12 vs. 2.17±0.1 and 2.14±0.12; p < 0.001). Choroidal thickness was significantly lower in patients without splenectomy than in patients with splenectomy and controls (260.05±61.02 vs. 305.11±42.13 and 298.89±29.14, p = 0.008). Parafoveal and perifoveal thickness of the full retina and outer retina were significantly lower in patients without splenectomy than in patients with splenectomy and controls (301.06±10.0, 279.78±10.28 vs. 311.04±14.89, 290.87±13.67 and 316.63±13.57, 289.56±9.31, p < 0.001 and p = 0.002; 174.72±7.81, 167.17±6.21 vs. 182.87±8.81, 173.60±7.09 and 185.11±9.26, 173.96±6.79, p = 0.001 and p < 0.001, respectively).ConclusionsOCTA findings can provide information about the microvascular effects of splenectomy on the retina of patients with TDβ-T. |
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