| 染色体外环状DNA在肿瘤中的研究进展 |
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| 引用本文： | 朱亚茹,訾彤,吴登龙,吴刚. 染色体外环状DNA在肿瘤中的研究进展[J]. 同济大学学报(医学版), 2023, 44(4): 601-608 |
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| 作者姓名： | 朱亚茹 訾彤 吴登龙 吴刚 |
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| 作者单位： | 同济大学附属同济医院泌尿外科，上海市200065 |
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| 基金项目： | 国家自然科学基金青年科学基金项目(81802560) |
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| 摘 要： | 染色体外环状DNA(extrachromosomal circular DNA, eccDNA)是一种来自染色体的双链环状DNA。eccDNA种类繁多，但其来源与功能仍尚不清楚。越来越多的证据表明eccDNA通过多种方式在癌症中发挥重要作用，且可能作为生物标志物参与肿瘤诊断与预后判断。本文综述eccDNA的分类、来源、功能等方面的研究进展，为eccDNA的研究提供参考。
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| 关 键 词： | 染色体外环状DNA；肿瘤；癌基因；生物标志物 |
| 收稿时间： | 2022-09-13 |
Research progress of extrachromosomal circular DNA in cancer |
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| ZHU Yaru,ZI Tong,WU Denglong,WU Gang. Research progress of extrachromosomal circular DNA in cancer[J]. Journal of Tongji University(Medical Science), 2023, 44(4): 601-608 |
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| Authors: | ZHU Yaru ZI Tong WU Denglong WU Gang |
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| Affiliation: | Department of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China |
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| Abstract: | Extrachromosomal circular DNA(eccDNA) is a double-linked circular DNA derived and free from chromosomes. There are many types of eccDNA, but its origin and function are still unknown. More and more evidences show that eccDNA plays an important role in cancer in a variety of ways, and may be used as a biomarker if tumor diagnosis and prognosis. Here, the classification, sources and functions of eccDNA are reviewed to provide reference for further eccDNA research. |
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| Keywords: | extrachromosomal circular DNA tumor oncogenes biomarker |
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