Effect of ethanol, acetaldehyde and acetate on the antioxidant-sensitive respiration in the perfused rat liver: influence of fasting and diethylmaleate treatment |
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| Authors: | L A Videla M I Villena |
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| Affiliation: | 1. Department of Biochemistry, School of Life Sciences, The Federal University of Technology, P.M.B. 704, Akure 340001, Nigeria;2. Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK;3. Department of Chemical Sciences, Skyline University Nigeria, Kano, Nigeria;4. Department of Chemistry, Physics and Atmospheric Science, Jackson State University, Jackson, MS 39204, USA;1. Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA;2. Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA;1. Department of Physiology, Faculty of Medicine, Karabuk University, Karabuk, Turkey;2. Department of Medical Biochemistry, Faculty of Medicine, Karabuk University, Karabuk, Turkey;3. Department of Biochemistry, Karabuk University Education and Research Hospital, Karabuk, Turkey;4. Department of Histology and Embryology, Faculty of Medicine, Mugla Sıtkı Kocman University, Mugla, Turkey;1. Health Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt;2. Biochemistry Division, Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-kom, Egypt;3. Zoology Department, Faculty of Science, Menoufia University, Menoufia, Egypt;4. Microbiology and Immunology Department, Faculty of Pharmacy, Galala University, New Galala city, Suez, Egypt;5. Drug Microbiology Lab., Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt;1. Guangxi Medical University, Nanning, China;2. Key Laboratory of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education, China |
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| Abstract: | The infusion of 45 mM ethanol or 50 microM acetaldehyde into the perfused rat liver produced comparable and significant antioxidant-sensitive respiratory rates, while marginal responses were obtained with 10 mM acetate. Ethanol-induced antioxidant-sensitive respiration was markedly increased in perfused livers from fasted rats or animals given diethylmaleate which exhibit low hepatic glutathione levels, compared to fed rats. These data point out the significant role of acetaldehyde in ethanol-induced liver oxidative stress, which can be exacerbated by glutathione depletion. |
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