肝炎肝硬化患者红细胞CR1粘附活性与肝功能损伤程度的相关性研究

目的研究肝炎肝硬化患者红细胞 CR1粘附活性与肝功能损伤严重程度的相关性。方法采用红细胞天然免疫粘附肿瘤细胞的测定方法对88例肝炎肝硬化病人、30例正常人的红细胞 CR1分子粘附活性进行测定,5个或以上红细胞牯附1个肿瘤细胞为一个结合单位,计算粘附率。结果肝炎肝硬化患者红细胞 CR1分子粘附活性显著低于正常人群(P<0.01),失代偿性肝硬化患者的红细胞 CR1分子粘附活性显著低于代偿性肝硬化患者(P<0.01),肝炎肝硬化患者红细胞 CR1分子粘附活性的变化与胆碱酯酶(CHE)密切相关,按 Child Pugh 分级。肝炎肝硬化患者随 Child 积分的升高,其红细胞 CR1分子粘附活性相应下降。结论肝炎肝硬化病人红细胞CR1分子粘附活性的变化与其病情的严重程度密切相关,该项可作为判断肝病患者肝功能损伤程度的重要指标。

A study on relationship between activity of erythrocyte CR1 immune-adhering tumor cell and severity of liver function in patients with liver cirrhosis

Objective To study the relationship between the activity of erythrocyte CR1 immune-adhering tumor cell and the severity of liver function in the patients with liver cirrhosis.Methods The assay of erythreeyte CR1 immune- adhering tumor cell was used in 30 cases of healthy individuals and 88 cases of patients with liver cirrhosis.One tumor cell rounded by at least five red cells was used as a rosette to calculate the ratios.Results The adhesion activity of ECR1 of patients with liver cirrhosis was obviously lower than that of healthy individuals (P<0.01).The adhesion activity of ECR1 of decompensated liver cirrhosis was obviously lower than that of the compensated liver cirrhosis (P<0.01).There was a good relationship between the activity of CER1 and the changes of CHE in patients of liver cirrhosis.The activity of CER1 was usually decreased when the level of severity of liver cirrhosis along with increase in Child Pugh.Conclusion There is a good relationship between the activity of ECR1 and the changes of CHE in patients with liver cirrhosis.It is important to assay the activity of ECR1 in the patients with liver cirrhosis.