p21ras,p53,c—myc,PCNA在子宫内膜腺癌中的表达

目的：探讨癌基因与子宫内膜腺癌的关系。方法：应用免疫组化ＬＳＡＢ法对３３例原发性子宫内膜膜癌进行Ｐ２１ｒａｓ，ｐ５３，ｃ－ｍｙｃ和ＰＣＮＡ的检测。结果：Ｐ５３表达来７８．８％，Ｐ２１ｒａｓ表达为５１．５％，ｃ－ｍｙｃ表达为８１．８％，ＰＣＮＡ表达为９７％。均明显高于正常增殖期子宫内膜。Ｐ２１ｒａｓ和Ｐ５３在正常子宫内膜无表达，因此比ｃ－ｍｙｃ在子宫内膜腺癌的表达更特异。本研究显示Ｐ５３与子宫内膜腺

Expression of p21 ras, p53, c myc, and PCNA in endometral adenocarcinoma

Purpose To explore the relation between oncogene and endometral adenocarcinoma; Methods The expressions of p21 ras, p53, c myc and PCNA were studied in 33 case of endometral adenocarcinoma by LSAB immunohistochemical technique; Results The results showed that the positivity rates of p53, pzlras, c myc and PCNA were 78 8%, 51 5%,81 8% and 97% respectively. The expressions of p21 ras, p53, c myc and PCNA in endometral adenocarcinoma were significantly higher than those in normal endometrum ( P< 0 05). The p21 ras expression was associated with metastasis ( P< 0 05). The p53 expression was correlated with histological grade ( P< 0 05). There was significant correlation between the expression of p53 and that of p21 ras in endometral adenocarcinoma ( P< 0 01). The coexpressions of p21 ras, p53 and c myc were 48 5%; Conclusions p53 cooperates with p21 ras in the pathogenisis and development of endometral adenocarcinoma. Endometral adenocarcinoma is the result of the cooperation of many oncogenes.