Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake |
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Authors: | Roncal-Jimenez Carlos A Lanaspa Miguel A Rivard Christopher J Nakagawa Takahiko Sanchez-Lozada L Gabriela Jalal Diana Andres-Hernando Ana Tanabe Katsuyuki Madero Magdalena Li Nanxing Cicerchi Christina Mc Fann Kim Sautin Yuri Y Johnson Richard J |
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Institution: | a Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80016, USAb Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville FL, USAc Instituto Nacional de Cardiología Ignacio Chávez, 14080 Mexico City, Mexico |
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Abstract: | Fructose induces metabolic syndrome in rats; but studies have been criticized for using high concentrations of fructose that are not physiologic, for using only pure fructose, and for not controlling for energy intake. We tested the hypothesis that a 40% sucrose diet (containing 20% fructose) might induce features of metabolic syndrome in male breeder rats independent of excess energy intake. Male Sprague-Dawley breeder rats were pair fed 40% sucrose or isocaloric starch diet for 4 months and evaluated for metabolic syndrome and diabetes. In vitro studies were performed in rat insulinoma cells (RIN-m5F) exposed to uric acid, and markers of inflammation were assessed. Rats fed a 40% sucrose diet developed accelerated features of metabolic syndrome with up-regulation of fructose-dependent transporter Glut5 and fructokinase. Fatty liver and low-grade pancreatic inflammation also occurred. Uric acid was found to stimulate inflammatory mediators and oxidative stress in islet cells in vitro. Sucrose, at concentrations ingested by a subset of Americans, can accelerate metabolic syndrome, fatty liver, and type 2 diabetes mellitus in male breeder rats; and the effects are independent of excess energy intake. |
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