| 癌基因HER2与乳腺癌的治疗 |
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| 引用本文： | 陈灿铭,沈镇宙,邵志敏. 癌基因HER2与乳腺癌的治疗[J]. 中国癌症杂志, 2000, 10(5): 446-448 |
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| 作者姓名： | 陈灿铭 沈镇宙 邵志敏 |
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| 作者单位： | 复旦大学医学院附属肿瘤医院乳腺外科,上海,200032 |
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| 摘 要： | ＨＥＲ２／ｃ－ｅｒｂＢ２是编码一种生长因子受体（ｐ１８５＾ＨＥＲ２）的癌基因，研究发现ＨＥＲ２基因的扩增和表达对于乳腺癌的预后具有重要意义，对于乳腺癌的治疗亦有重要的指导作用。针对ｐ１８５＾ＨＥＲ２的单克隆抗体Ｈｅｒｃｅｐｔｉｎ能有效抑制ｐ１８５＾ＨＥＲ２高表达的乳腺癌细胞的生长，为乳腺癌的治疗提供了一种新的手段。而针对ＨＥＲ２表达产物ｐ１８５＾ＨＥＲ２的疫苗的研究将可能是乳腺癌治疗的一个重要的突
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| 关 键 词： | HER2 p185^HER2 Herceptin 乳腺癌 疫苗 癌基因 |
| 文章编号： | 1007-3639(2000)05-0446-03 |
| 修稿时间： | 2000-07-14 |
HER2 and treatment of breast cancer |
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| CHEN Can ming,SHEN Zhen zhou,SHAO Zhi min. HER2 and treatment of breast cancer[J]. China Oncology, 2000, 10(5): 446-448 |
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| Authors: | CHEN Can ming SHEN Zhen zhou SHAO Zhi min |
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| Abstract: | HER2/c erbB2 is a human oncogene which encodes a 185 kDa transmembrane glycoprotein receptor (p185 HER2 ). The amplification and overexpression of HER2 have a major role in the treatment and the prognosis of breast cancer. The antibody to the p185 HER2 ,Herveptin,can potently inhibit the growth of human breast cancer that overexpress p185 HER2 , which provides a new measure for the treatment of breast cancer. The research of vaccine to p185 HER2 for breast cancer may be a breakthrough in the treatment of breast cancer. |
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| Keywords: | HER2 p185 HER2 herceptin breast cancer vaccine |
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