细胞粘附分子-1在涎腺腺样囊性癌的表达及临床意义

目的 探讨细胞粘附分子－1（ICAM－1）在腺样囊性癌中的表达及其临床意义。方法 采用免疫组织化学SP法检测31例腺样囊性ICAM－1的表达情况。结果 在腺样囊性癌管状型、混合型、实体型中ICAM－1表达率为88．24％，66．67％，25％。31例发肿瘤最大直径≥3cm者无1例高表达，直径＜3cm者有12例高表达，12例复发或淋巴结转移；ICAM－1在直径≥3cm和复发转移组中的表达显著低于直径＜3cm及无复发转移者（P＜0．01）。结论 涎腺腺样囊性癌ICAM－1的表达与组织分化程度、肿瘤进展及复发、转移有关，ICAM－1高表达者复发转移较低。ICAM01可作为预后指标。

Expression and Clinical Significance of Inter-Cellular Adhesion Molecule-1in Salivary Gland Adenoid Cystic Carcinoma

Objective\ To study the expression and clinicopathological significance of inter\|cellular adhesion molecule\|1(ICAM\|1) in salivary gland adenoid cystic carcinoma(SGACC).\ Methods\ The SP immunohistochemical method was used to examine the expression of ICAM\|1 in 31 cases of SGACC.\ \{Results\}\ The positive rates of ICAM\|1 in classic cribri\|tubiform, mixed and solid patterns of SGACC were 88 24%, 66 67% and 25 00%.\ The expression of ICAM\|1 related to the diameter of primary carcinoma.\ None in 9 cases with tumor larger than 3 cm showed high expression, while 12/22 cases with tumor smaller than 3 cm had high expression.\ The expression of ICAM\|1 in cases with recurrence, lymph node metastasis or tumor larger than 3 cm in diameter was obviously weaker than those without recurrence or lymph node metastasis, or with tumor less than 3 cm(P<0 01).\ Conclusion\ The expression of \{ICAM\|1\} in SGACC correlates with their differentiation, recurrence and metastasis.\ The cases with \{higher\} level expression of ICAM\|1 have low rate of recurrence and metastasis, thus indicating it is a stronger anticancer immunity.