| 犬颈动脉内皮损伤后胰岛素样生长因子-1与增殖细胞核抗原的动态变化 |
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| 引用本文： | 范晨,刘一之,周岱,王中. 犬颈动脉内皮损伤后胰岛素样生长因子-1与增殖细胞核抗原的动态变化[J]. 苏州大学学报(自然科学版), 2008, 28(1): 44-46 |
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| 作者姓名： | 范晨 刘一之 周岱 王中 |
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| 作者单位： | 范晨（苏州大学附属第一医院,介入科,江苏,苏州,215006）;刘一之（苏州大学附属第一医院,介入科,江苏,苏州,215006）;周岱（苏州大学附属第一医院,神经外科,江苏,苏州,215006）;王中（苏州大学附属第一医院,神经外科,江苏,苏州,215006） |
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| 摘 要： | 目的 探讨胰岛素样生长因子-1(IGF-1)及增殖细胞核抗原(PCNA)在犬颈动脉球囊损伤后血管再狭窄形成中的作用.方法 采用ELISA法检测IGF-1在犬颈动脉球囊损伤后血管狭窄形成过程中表达的动态变化,同时采用免疫组化检测目标血管的PCNA变化规律,结合影像学测量方法观察犬颈动脉狭窄的形成过程.结果 IGF-1的释放在球囊血管成形术后4-6 h[(平均值(942.55±44.13)ng/ml、(1073.09±87.73)ng/ml]启动,到术后12h[平均值(1468.35±101.85)ng/ml]达到峰值,至术后72 h[平均值(1405.64±85.09)ng/ml]维持高水平释放;犬颈动脉球囊损伤后4周内即发生血管增生性变化,PCNA阳性细胞数于术后4周达到峰值[平均值(61.60±1.96)个,视野],至术后8周左右血管狭窄形成.结论 IGF-1表达增强与颈动脉内皮损伤后血管增生性变化有关,为较理想的血管成形术后动脉狭窄发生的启动信息,PCNA表达增强反映血管内皮增殖高峰在颈动脉内皮损伤后4周.
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| 关 键 词： | 颈动脉再狭窄 球囊血管成形术 介入 颈动脉内 皮损 伤后 胰岛素 样生长因子 增殖细胞核抗原 态变化 Model Canine Angioplasty Stenosis Carotid Artery Growth Expression Alteration 血管内皮 启动信息 犬颈动脉狭窄 增强 周达 |
| 文章编号： | 1673-0399(2008)01-0044-03 |
| 修稿时间： | 2007-01-18 |
Dynamic Alteration of Expression of the Insulin-like Growth Factor-1 on Carotid Artery Stenosis after Ballon Angioplasty in Canine Model |
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| FAN Chen,LIU Yi-zhi,ZHOU Dai,WANG Zhong. Dynamic Alteration of Expression of the Insulin-like Growth Factor-1 on Carotid Artery Stenosis after Ballon Angioplasty in Canine Model[J]. Suzhou University Journal of Medical Science, 2008, 28(1): 44-46 |
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| Authors: | FAN Chen LIU Yi-zhi ZHOU Dai WANG Zhong |
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| Affiliation: | FAN Chen1,LIU Yi-zhi1,ZHOU Dai2,WANG Zhong2(1.Dept of Interventional Radiology,2.Dept of Neurosurgery,the First Hospital Affiliated to Suzhou University,Jiangsu Suzhou,215006,China) |
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| Abstract: | Objective To investigate the effect of insulin-like growth factor-1(IGF-1) and proli-ferating cell nuclear antigen(PCNA) on carotid artery stenosis after ballon angioplasty in canine model.Methods Alteration of IGF-1 expression in formation of carotid artery stenosis after ballon angioplasty in canine model was examined by ELISA and VSMCs proliferation was examined by PCNA,the process of carotid artery stenosis was reflected by immunohistochemistry and imageology methods.Results IGF-1 release started up at ... |
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| Keywords: | carotid artery restenosis ballon angioplasty intervention |
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