Alzheimer病与Parkinson病患者记忆损害的比较研究

目的：测查Alzheimer病、Parkinson病患者的记忆功能，了解这两种疾病病人记忆损伤的特征。方法：采用多维记忆评估量表中的12个分测验对30例原发性Parkinson病患者、30例临床诊断可能的Alzhdmer病患者及年龄、性别和教育程度与2个病人组相匹配的2个正常对照组进行外显记忆、内隐记忆及日常生活记忆等记忆功能的评定。结果：AD组在所有的分测验和记忆因子上均差于对照组；PD组在图画再认、数字广度、汉词回忆、图形再生、经历定向等分测验和记忆广度、再认记忆、自由回忆、日常记忆、外显记忆等记忆因子上均显著低于对照组：经以教育年限为协变量校正后发现。除自由组词、残图命名、数字广度、空间广度、汉词回忆、常识记忆、记忆广度、内隐记忆外，AD组在其余各分测验和记忆因子上均存显著差于PD病人组。结论：AD病人存在着广泛的记忆功能障碍：PD病人存在着工作记忆和策略记忆的障碍：两者的记忆功能障碍存在着明显的不同。

A Comparative Study of Memory Disorders in Patients with Alzheumer''''s Disease and Parkinson''''s Disease

Objective: To explore the memory disorders in patients with Parkinson's disease and Alzheimer's disease. Methods: 12 subtests of MMAS were administrated to 30 patients with idiopathic PD, 30 patients with AD, and two matched control groups. Results: All the performance of patients with AD was significantly worse than that of normal controls. The performance of patients with PD was significantly worse in picture recognition, digit span, word recall, picture reproduction, orientation,memory span, recognition, free recall, everyday memory, explicit memory than that of normal controls. With education years controlled, except word-stem completion, degraded picture naming, digit span, spatial span, word recall, memory span, and implicit memory, there were significant differences in the other memory performance between PD and AD group. Conclusion: AD patients manifested extensive memory disorder; patients with PD manifested difficulties in working memory and strategy memory; there were significant differences in memory disorder between AD and PD patients.