Effect of taurine on calcium kinetics of guinea-pig heart |
| |
| Authors: | P Dolara A Agresti A Giotti G Pasquini |
| |
| Affiliation: | 1. Institute of Pharmacology, University of Florence, Viale Morgagni 65 Via delle Gore 2, Firenze, Italia;7. Centro di Calcolo, University of Florence, Via delle Gore 2, Firenze, Italia |
| |
| Abstract: | Guinea-pig hearts, perfused with Tyrode containing 8 mM taurine, show a less marked decrease of contractile force when washed out with calcium-free Tyrode than control hearts. The effects of taurine cardiac contractility are explained by its interference with calcium kinetics. Total calcium content is increased in taurine-treated hearts, and greater amounts of calcium are washed out from calcium exchanging compartments, analyzed according to the model of Bayley et al. (1968). Most of the additional calcium retained by taurine-treated hearts is bound to some tissue structure, and can be partially mobilized when the concentration of easily exchanged calcium falls. The hypothesis is advanced that taurine increases the affinity of some cell structure for calcium. |
| |
| Keywords: | Taurine Guinea-pig heart Calcium kinetics |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
