急性冠状动脉综合征生物标志物的研究现状

随着冠心病发病率的逐年升高,人们对急性冠状动脉综合征生物标志物的研究也不断深入。目前临床上常用于诊断急性冠状动脉综合征的生物标志物有肌红蛋白、肌酸激酶同工酶、肌钙蛋白、高敏肌钙蛋白等。越来越多的生物标志物被发现可用于急性冠状动脉综合征的早期诊断、风险分层和预后评估。目前研究发现的心脏生物标志物按其产生机制和生理效应分为心肌细胞损伤生物标志物、内皮细胞相关生物标志物、生物机械应变标志物、炎症因子相关标志物等几大类,文章对该领域近来年的研究进展进行综述。

Research status of biomarkers for acute coronary syndrome

With the incidence rate of coronary heart disease increasing year by year, the research on biomarkers of acute coronary syndrome has been deepened. At present, the clinical biomarkers commonly used in the diagnosis of acute coronary syndrome are myoglobin, creatine kinase isoenzyme, troponin, hypersensitive troponin and so on. More and more biomarkers have been found to be useful for early diagnosis, risk stratification and prognosis evaluation of acute coronary syndrome. According to the mechanism and physiological effect of cardiac biomarkers, they can be divided into myocardial cell injury biomarkers, endothelial cell related biomarkers, biomarkers of biological mechanical strain, inflammatory factor related biomarkers and so on. This paper reviews the research progress in this field in recent years.